131106outline5 - Biol. 1311 9/8/06 What hemoglobin does...

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Biol. 1311 – 9/8/06 – What hemoglobin does What it means to “bind” oxygen As you reasoned out: It isn’t a “shield” but a trap The trap size is limited: if O 2 continues to increase, it fails Conclusion: the protection is transient What happens when threat is gone? Hb slowly releases Major lesson here: a lot of molecular interactions are reversible Also allows us to understand how the trap works Paper wads I Wad up a sheet of paper – play catch with a neighbor Throw as fast as you can Now switch to your “off” hand (left for rh, right for lh) For which game of catch did the wad spend the most time in your hand? Concept of affinity: Hb has a high affinity for O 2 (“catches” it well) Figure 44.12a shows how affinity can be given a number Definition of partial pressure as relative measure of O 2 Paper wads 2 Form a group with 4 or so neighbors. Designate 1 as the Hb The Hb catches a wad and holds it for 2 counts, then lets go Trial 1: non-Hb’s gently toss wads at Hb as fast as possible
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This note was uploaded on 01/24/2010 for the course BIO 1311 taught by Professor Shinkle during the Fall '06 term at Trinity University.

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131106outline5 - Biol. 1311 9/8/06 What hemoglobin does...

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