131106outline12 - Biol. 1311 9/25/06 An old globin does new...

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Biol. 1311 – 9/25/06 An old globin does new tricks Finally we get back to hemoglobin specific information A preview of transcription in eukaryotes (Fig 18.1) DNA is mostly tightly packed and inaccessible (Fig 18.2) Packing is dynamically regulated (Fig. 18. 4) When unwound, DNA is acted on by transcription factors (Fig 18.7) Transcription factors bind at specific sequences Some at promoter, some nearby, some distant Coding sequences are interrupted – what’s up with that? (Fig. 16.6) And just one bit more on translation In mammals heme influences whether or not globin is translated What the previous diagram is about HCI = heme controlled inhibitor eIF-2 = eukaryotic initiation factor 2 Must get a new GTP every time it initiates (sound familiar?) GEF helps it do so When heme is high, HCI is inactive This should sound like lac repressor When heme is low HCI stops eIF-2 from “refueling” with GTP Results in no further translation This is an example of regulation at the level of translation (Fig 17.1)
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131106outline12 - Biol. 1311 9/25/06 An old globin does new...

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