131106outline14 - Biol.1311 9/29/2006 explaining the last...

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Biol.1311 – 9/29/2006 – explaining the last of Hardison through gene regulation Treating bases as characters (no eq. figure) Alternative to Fig. 26.4 How would you figure out which was the ancestral state?? Add in a second base as a second character; 7 total changes complete the tree DNA sequence level analysis of Hardison’s regulatory regions (H9) And all this ties in with gene regulation (no eq. fig.) So regulation of transcription in eukaryotes is clearly complex (Fig 18.1) Structure of chromatin can actually be even more complex (no eq. fig) The only time packing is this tight is when it is time to move whole chromosomes (NEF) Still, DNA is mostly tightly packed and inaccessible (Fig 18.2) But packing is dynamically regulated to create access (Fig. 18. 4) When unwound, DNA is acted on by transcription factors (Fig 18.7) Transcription factors bind at specific sequences Some at promoter, Some nearby, Some distant So enhancers can be inserted into introns (but Hb enhancers are upstream)
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This note was uploaded on 01/24/2010 for the course BIO 1311 taught by Professor Shinkle during the Fall '06 term at Trinity University.

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131106outline14 - Biol.1311 9/29/2006 explaining the last...

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