Problem set 3 - a. Can the ketoglutarate formed in the...

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Problem set 3: All problems are assigned from the 6 th edition of biochemistry by Stryer et al. Chapter 17: Krebs cycle Pg. 499-500 1 (tricky), 4, 5 (tricky), 6, 7, 11, 13, 14 #5: The hydrogen on the carbon between the nitrogen and the sulfur atoms can be lost as a proton, forming a carbanion. Formation of the carbanion is ESSENTIAL for TPP function! So you think you know the Krebs cycle eh? Try this out! The amino acid glutamate can be converted into α–ketoglutarate by glutamate dehydrogenase as shown below (note: you are not responsible for this reaction).
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Unformatted text preview: a. Can the ketoglutarate formed in the above reaction enter the Krebs cycle? Write out the balanced equation for the conversion of glutamate to oxaloacetate. Would this result in a net production of oxaloacetate? b. The above reaction is reversible, i.e. ketoglutarate can be converted to glutamate. What effect would the synthesis of glutamate by this reaction have on the overall rate of the Krebs cycle? Explain your answer. c. Could an increase in the concentration of acetyl CoA overcome the effect observed in b?...
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This note was uploaded on 01/25/2010 for the course SCIENCE bioc300 taught by Professor Foster during the Spring '10 term at The University of British Columbia.

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