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Glycolysis & Gluconeogenesis Regulation

Glycolysis & Gluconeogenesis Regulation -...

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Glycolysis and Gluconeogenesis are Reciprocally Regulated - if both were highly active at the same time, the net result would be the hydrolysis of four nucleoside triphosphates (2 ATP and 2 GTP) - both are extremely exergonic under cellular conditions - rate of glycolysis is determined by [glucose] - rate of gluconeogenesis is determined by [pyruvate] and [other precursors of glucose] signal molecule: fructose 2,6-bisphosphate levels are HIGH when fed, and LOW when starved. We can only make glucose when energy levels are relatively high, when energy/glucose ratio is high. Phosphofructokinase 1 (PFK1) <proceeding with Glycolysis> - stimulated by high levels of AMP (energy charge is LOW) make more ATP - strongly stimulated by high levels of F-2,6-BP in the liver make more ATP - inhibited by high levels of ATP (energy charge is HIGH) make less ATP - inhibited by high levels of citrate (Krebs cycle is generating a lot of high energy electrons) make less ATP Fructose 1, 6-bisphosphatase (FBPase 1)
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