Unformatted text preview: o > 2 o > 3 o favored by: good leaving group strong, basic nucleophile lack of steric hindrance polar aprotic solvents mechanistically: single step - 1 transition state backside displacement inversion of stereochemistry Cl Cl H H cis-1,3-dichlorocyclopentane?-Good leaving groups are weak bases. Weak bases spread out charge. I > Br > Cl >>F-Strong nucleophiles are strongly basic, highly localized charge and not sterically hindered...
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- Spring '07
- Isomers, Conformational isomerism, Steric effects, Winnie Chan, Café Roma, 57 kcal