320Fall09Lecture18 - BI O 320 Cell Biology, Fall 09 Dr....

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Unformatted text preview: BI O 320 Cell Biology, Fall 09 Dr. Thomas Bushar t Lecture 18 Topics Filament binding proteins Filament organization Motor proteins - myosin Filament binding proteins Formed filaments can interact with proteins Change stability Link filaments Sides and ends potential interaction points MT side-binders M icr otubule-associated pr oteins (MAPs) MAP2 and tau are found in neurons I nteract with multiple MTs Actin side-binders Tropomyosin Stabilizes Prevents other proteins binding Cofilin (actin depolymerizing factor) Twists filament more tightly (stability?) Promotes minus end dissociation (treadmilling?) Binds to ADP-actin (old vs new filaments?) Filament end-binders Lower concentrations necessary Few ends vs. long lengths May stabilize fiber or promote dissociation Regulation possible Actin caps Minus end ARP complexes Tropomodulin binds to tropomyosin coated filaments Plus end capping proteins Slows growth and shrinkage CapZ Gelsolin Microtuble caps...
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This note was uploaded on 01/25/2010 for the course BIO 51055 taught by Professor Bushart during the Fall '09 term at University of Texas at Austin.

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320Fall09Lecture18 - BI O 320 Cell Biology, Fall 09 Dr....

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