320Fall09Lecture12

320Fall09Lecture12 - BIO 320 Cell Biology Fall 09 Dr Thomas...

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BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 12
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Topics Endoplasmic reticulum
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Endoplasmic reticulum Large membrane network ER lumen is topologically equivalent to the lumen of many other organelles and outside of the cell Functions I Site of membrane protein and lipid production for nearly all organelles I Produces most of the lipids for mitochondrial and peroxisomal membranes I Storage of ions (notably Ca 2+ )
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ER import overview Signal sequence & receptors Transport is most often a co-translational process I Ribosomes must associate with ER membrane I No need for cytosolic chaperones Post-translational transport similar to mitochondrial translocation I Chaperone association with polypeptide Figure 12-35 Molecular Biology of the Cell (© Garland Science 2008)
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Co-translational import Requires association of ribosomes with membrane Rough ER is defined by presence of ribosomes Figure 12-36a Molecular Biology of the Cell (© Garland Science 2008)
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Sequence recognition Signal-recognition particle (SRP) I Mobile cytosolic element I Adaptor-like in functionality I General in sequence recognition Thylakoid
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SRP binding domain Lined with methionines Figure 12-39a Molecular Biology of the Cell (© Garland Science 2008)
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This note was uploaded on 01/25/2010 for the course BIO 51055 taught by Professor Bushart during the Fall '09 term at University of Texas.

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320Fall09Lecture12 - BIO 320 Cell Biology Fall 09 Dr Thomas...

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