320Fall09Lecture16 - BIO 320 Cell Biology, Fall 09 Dr....

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BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 16
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Topics Synaptic vesticles Cytoskeletal filaments I General I Actin filaments I Microtubules I Intermediate
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Transport rates New membrane growth may need to be rapid I Ca 2+ increase at wound sites
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Vesicle targeting Directional transport aids in cell polarity Direct I Cytoplasmic signal sequences recognized by coat proteins Indirect I Retrieval from PM, sorted appropriately at endosomes Lipid rafts I Autonomous formation and sorting
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Direct vs indirect
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Lipid rafts Rafts tend to head to apical regions I GPI-anchored proteins found at apical regions
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Nerve vesicle formation New vesicles can be formed directly from endocytic vesicles (Why necessary?)
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Synaptic vesicles
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Cytoskeleton Functions of structure and movement require three types of protein filaments and associated proteins I Intermediate filaments I Microtubules I Actin filaments I Accessory proteins Motor proteins
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Filaments made from subunits Subunit advantage I Small amount of DNA can produce large structures I Assembly and disassembly are controllable Growth and shrinkage of cytoskeletal fibers I Error correction Badly made subunits simply won’t be used “Polymers” are through non-covalent interactions between subunits I Rapid, low-energy changes
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320Fall09Lecture16 - BIO 320 Cell Biology, Fall 09 Dr....

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