320Fall09Lecture17 - BIO 320 Cell Biology Fall 09 Dr Thomas Bushart Lecture 17 Topics Intermediate filaments Drugs and poisons Cytoskeletal

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon
BIO 320 Cell Biology, Fall ‘09 Dr. Thomas Bushart Lecture 17
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Topics Intermediate filaments Drugs and poisons Cytoskeletal regulation I MT and actin nucleation
Background image of page 2
Fiber conservation Actin and tubulin are very similar across species I Evolutionarily constrained due to interactions
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Intermediate filaments Less widely used, related to nuclear lamins Structurally distinct from actin and microtubules I Rope-like I Strong (against pulling) I Flexible Found most often in cells exposed to mechanical stress
Background image of page 4
Intermidiate filaments monomer dimer Antiparallel tetramer Soluble subunit
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Intermediate filaments Ends are the same so no polarity 8 tetramers = 16 anti-parallel dimers Phosphorylation likely modulates dissasembly
Background image of page 6
Filament strength Microtubules networks “stretch” easily but break quickly Actin filaments are more rigid but can withstand greater force Intermediate filaments networks are highly flexible and resistant to high forces
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Microtubules
Background image of page 8
Actin filaments
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Intermediate filaments
Background image of page 10
Cytoskeleton network
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Intermediate filament uses Keratins used in hair, nails, skin, scales Holding neighboring cells together I Keratin network I Joined at desmosomes Vimentin-like I Desmin important for mouse muscle cell development
Background image of page 12
Keratin filament diseases Blistering disorders – mechanical stresses rupture basal cells I Skin, mouth, esophageal lining, cornea I Associated with head-region abnormalities
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Neurofilaments Filaments run the length of axons Important for axonal growth and function
Background image of page 14
Image of page 15
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/25/2010 for the course BIO 51055 taught by Professor Bushart during the Fall '09 term at University of Texas at Austin.

Page1 / 41

320Fall09Lecture17 - BIO 320 Cell Biology Fall 09 Dr Thomas Bushart Lecture 17 Topics Intermediate filaments Drugs and poisons Cytoskeletal

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online