320Fall09Lecture22 - BI O 320 Cell Biology, Fall 09 Dr....

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Unformatted text preview: BI O 320 Cell Biology, Fall 09 Dr. Thomas Bushar t Lecture 22 Topics Cell adhesions Tight junctions Gap junctions Basal laminae Adhesion ability Cadherin binding is homophilic E-Cadherin to E-cadherin Repeated cadherin domains Knob to pocket binding at N-terminal tips Cadherins in development Cells may need to alter associations Releasing attachment important to allow for migration Mesenchymal cells unattached cells Changing cells and their associations mirrored in changes in cadherin expression Suppression of cadherins important for epithelial- mesenchymal transitions Twist likely suppresses expression Cancer malignancy involves escape from epithelial neighbors Neural tube development E-Cadherin N-Cadherin I ntracellular anchor prot eins Catenins anchor cytoplasmic cadher in tail to actin or int er mediate filaments Attachments may be regulat ed p120? Adhesion belts Actin bundling proteins ( -actinin) + myosins Desmosome organization Rivet-like junctions connecting intermediate filaments (keratin in most epithelia) Desmosome disorders cause blistering much like keratin disorders Desmosome structure A.K.A -catenin Selectins Lectins are cell-surface carbohydrate- binding proteins Selectins mediate transient, Ca 2+-dependent, cell-cell interactions in the vascular system L-selectin on WBCs P-selectin on platelets and inflamed endothelial cells E-selectin on activated endothelial cells Heterophilic binding WBC rolling Low affinity selectin binding allows for rolling High affinity integrin binding traps cell at sites of inflammation I mmunogolobulin superfamily is Ca 2+ independent Contain I g-like domains I nvolved in fine tuning of cell adhesions Some involved in signaling pathways I ntercellular cell adhesion molecules (I CAMs) and Vascular cell adhesion molecules (VCAMs) Heterophilic binding (to integrins)...
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This note was uploaded on 01/25/2010 for the course BIO 51055 taught by Professor Bushart during the Fall '09 term at University of Texas at Austin.

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320Fall09Lecture22 - BI O 320 Cell Biology, Fall 09 Dr....

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