320Fall09Homework7_key - Cell Biology (BIO 320), Fall 2009,...

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Cell Biology (BIO 320), Fall 2009, Dr. Bushart Homework set #7 1. What transport activities in the cell would be negatively impacted by a lack of H + - ATPases? There are numerous ones, but try to come up with at least four (more is better!). Explain how proton transport is important for each example. Some transport we’ve looked at utilize pH as a means to modulate cargo binding by transport receptors. This is the case for at least three different receptors: the KDEL receptor, the M6P receptor, and even the transferrin receptor. Protons also have roles in active transmembrane transport, being used as a concentration gradient. There are a number of different possibilities, but one recent one is the H+-glutamate exchanger in synaptic vesicles. The charge difference partly from the proton gradient was also used in mitochondria to drive the uptake of the signal peptide in mitochondrial transport. pH and acidification of compartments also play roles in protein processing during transport. pH may allow transported enzymes to become active (as in the case of acid hydrolases) or contribute to their aggregation (as in the concentration of secreted proteins during regulated exocytosis). 2.
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This note was uploaded on 01/25/2010 for the course BIO 51055 taught by Professor Bushart during the Fall '09 term at University of Texas.

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320Fall09Homework7_key - Cell Biology (BIO 320), Fall 2009,...

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