Genetics380_2009_Lecture1and2

Genetics380_2009_Lecture1and2 - Genetics 380 Le ct u r e s...

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1 Genetics 380 Introduction to Genetics, Human Disease, Molecular Biology, and Biotechnology Maureen M. Barr, Ph.D. [email protected] Welcome to Genetics 380! A few announcements… Pick up today’s HANDOUT that has syllabus and important course information. Powerpoint lectures will be available on Sakai. Instructor and TA introductions Genetics 380 FAQs How do I get a special permission number? Contact Cathie Alia, Office of Undergraduate Instruction, Nelson Labs - Room B112 [email protected] . rutgers . edu Can I switch my recitation section? Start by asking your TA. Otherwise, contact Cathie Alia (above). DO NOT DROP AND TRY TO ADD A NEW SECTION. Is the text required? Pierce 3rd Edition is recommended. A copy of Pierce 3rd edition will be on reserve at Alexander, Mabel Smith Douglass, and LSM libraries. Is homework graded? Your TA will check that assignments are complete and on time. Problems will be discussed in recitation section. Is the final cumulative? NO, but it is on Dec. 23rd. Will the exam cover things in the text but not in lecture? NO. But the text will go into greater explanation on lecture topics, which may be very helpful.
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2 How does Genetics impact our daily lives? What is genetics???? The science of heredity and the variation of organisms. In medicine, genetics is the study of variation associated with illness and death. Genetics from a Biotechnology Timeline http://www.ncabr.org/bioman/ 8000-4000 B.C. Humans domesticate crops and livestock. Potatoes first cultivated for food.
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3 2000 B.C. Biotechnology used to leaven bread and ferment beer, using yeast (Egypt). Production of cheese, fermentation of wine begins (Sumeria, China, Egypt). 500 B.C. First antibiotic: Moldy soybean curds (tofu) used to treat boils (China). 100 B.C. First insecticide: powdered chrysanthemums (China)
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4 1797 First vaccination Edward Jenner takes pus from a cowpox lesion, inserts it into an incision on a boy's arm. 1830-1833 1830 Proteins are discovered. 1833 First enzyme is discovered and isolated. Model of a 5-peptide protein. 1857 Louis Pasteur proposes that microbes cause fermentation. He later conducts experiments that support the germ theory of disease.
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5 1859 Charles Darwin publishes the theory of evolution by natural selection. 1865 Gregor Mendel discovers the laws of inheritance by studying plants in his garden. The science of genetics begins. 1869 DNA isolated (nuclein) 1879 Mitosis described (Fleming) 1900 Rediscovery of Mendel’s work 1900 Drosophila used in early studies of genes 1902 Chromosome Theory of Inheritance (Sutton) 1902 Inborn Errors of Metabolism (Garrod) 1909 The word “gene” is coined to describe Mendel’s unit of inheritance (Johannsen) 1911 Chromosomes carry genes (Morgan)
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6 1927 Herman Muller discovers that radiation causes defects in chromosomes. 1928
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This note was uploaded on 01/26/2010 for the course GENETICS 380 taught by Professor Glodowski during the Fall '08 term at Rutgers.

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Genetics380_2009_Lecture1and2 - Genetics 380 Le ct u r e s...

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