BIOL 595 12-1-09 (F 2009) - BIOL 595 Lecture...

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BIOL 595 Lecture Cardiac Development (II) 12-1-09
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Left and Right Cardiac Asymmetry
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BIOL 395Y Situ Situs Inversus Complete mirror-image reversal of handedness  (1/10,000 – a rare individual) Figure 3.40 Page 122
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Figure 3.41 Page 123 Determination of L/R Asymmetry in the Chick
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Activation of Left-sidedness of Gene Expression Expression of Nodal and Pitx2 Cardiac Randomization can be caused by: 1)Absence of Nodal or Pitx2 expression 2)Bilateral expression of either Nodal or Pitx2
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Cilia-directed Flow Generation Figure 3.42 Page 124
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Nodal Flow in the Node
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The Role of Bmp Signaling in L/R Cardiac Asymmetry
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Conflicting Data for the Role of Bmp Signaling in L/R Cardiac Asymmetry In Chick: 1)Bmp4 expresses asymmetrically in the Hensen’s node with the strongest expression on the right side 2)The strong Bmp4 expression on the right side activates Fgf8 expression and prevents initiation of Nodal expression in the right lateral plate mesoderm
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Conflicting Data for the Role of Bmp Signaling in L/R Cardiac Asymmetry In Mouse with deficient for Smad5: 1)Lefty1 is expressed at a very low level 2)Nodal, Lefty2 and Pitx2 are expressed bilaterally Conclusion: These findings demonstrated that in chick and mouse Bmp signaling is required for right- sided laterality, via repression of Nodal expression in the right lateral plate mesoderm
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In chick, Bmp2 has been shown to positively regulate
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This note was uploaded on 01/27/2010 for the course BIOL 595 taught by Professor Staff during the Spring '08 term at Purdue University-West Lafayette.

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BIOL 595 12-1-09 (F 2009) - BIOL 595 Lecture...

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