BIOL 595 11-17-09 (F2009) - BIOL 595 Sex Determination (II)...

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BIOL 595 11-17-09 Sex Determination (II)
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Sex Determination in Mammals 1) Primary sex determination – gonadal  sex (XX or XY) 2) Secondary sex determination – external  phenotype
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The formation of ovaries and of testes are both  active, gene-directed processes.  There is no  “default state” in mammalian primary sex  determination
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Regulatory Control in the Formation of the Male and Female Sex Organs Bioethics Figure 5.4
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Wnt4 Represses testosterone production in the undifferentiated gonad SRY Functions to downregulate of wnt4 expression, which occurs when Sertoli cells differentiate
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-A potential testes-suppressing gene on the X- chromosome - Nuclear hormone receptor DAX1 SOX9 -HMG transcription factor - Activated by SRY - Binds to the promoter of anti-Mullerian hormone gene
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SF-1 -Steroidogenic factor 1 (transcription factor) - Activated by SRY - Required for making the bipotential gonad - Declined in the genital ridge of XX embryos - Stays on in the developing testes - Functions together with Sox9 to elevate the levels of AMH transcription
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This note was uploaded on 01/27/2010 for the course BIOL 595 taught by Professor Staff during the Spring '08 term at Purdue University-West Lafayette.

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BIOL 595 11-17-09 (F2009) - BIOL 595 Sex Determination (II)...

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