BIOL 595 11-24-09 (F 2009)

BIOL 595 11-24-09 (F 2009) - BIOL 595 Lecture...

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BIOL 595 Lecture Cardiac Development (I) 11-24-09
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Heart is a Mechanical Pump Atrium – collecting chamber Ventricle – pumping chamber   
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Different Types of Hearts
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Vertebrate Heart 1) First organ to form during organogenesis 2) Mesodermal origin 3) First established as a single tube of two epithelial layers a) Inner endocardium b) Outer myocardium
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Key Steps in Forming a Functional Heart
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Early Heart Development in the Mouse Figure 9.47 Page 378
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Schematic Human Heart Development Figure 9.48 Page 379
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Cardiac Looping and Chamber formation
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Valve Formation
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Heart Valves 1) Separate Chambers 2) Guard the arteries to prevent reflux 3) Guard the conduction system to coordinate the timing and  efficiency of chamber filling and ejection
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In humans about 1 in 100 live-born infants  have some congenital heart malformation,  while in utero heart malformation leading  to death of the embryos is between 5 and  10%
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Specification of Cardiac Progenitor Cells
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BIOL 595 11-24-09 (F 2009) - BIOL 595 Lecture...

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