Lecture 9 - The structure of DNA led Watson and Crick to...

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Unformatted text preview: The structure of DNA led Watson and Crick to propose that DNA is replicated in a semi-conservative way where each strand acts as a template to direct the synthesis of the second strand 5 AGTCTTAGCTAGGTACTCA 3 3 TCAGAATCGATCCATGAGT 5 5 AGTCTTAGCTAGGTACTCA 3 3 TCAGAATCGATCCATGAGT 5 5 AGTCTTAGCTAGGTACTCA 3 3 TCAGAATCGATCCATGAGT 5 Fig. 6.15 Properties of DNA polymerase: 1. Needs to have a template. 2. It can only add nucleotides to the 3 hydroxyl (OH) of a nucleotide. Therefore DNA replication always proceeds in the 5 to 3 direction. 3. DNA polymerase can only add nucleotides to to an existing single strand of nucleic acid. Therefore DNA synthesis must always be primed by a small piece of RNA or DNA. For replication of chromosomes RNA primers are used. For the polymerase chain reaction (PCR), DNA primers are used. QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture....
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Lecture 9 - The structure of DNA led Watson and Crick to...

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