mcb450-10f09 - Chapter 10 Nucleotides and Nucleic Acids...

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Chapter 10 Nucleotides and Nucleic Acids Mintel Office Hours – Noyes 208 Today – 12:30-1:00 PM
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Fig. 10-CO, p. 291 Watson Crick
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Central Dogma of Molecular Biology DNA resides in the nucleus, replicates, and is transcribed into RNA. RNA exits the nucleus and encodes the synthesis of protein in the cytoplasm in the process of translation .
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Fig. 10-1, p. 292
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Fig. 10-2, p. 292 Purines and Pyrimidines Note conjugated double bonds.
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Fig. 10-3, p. 292 Pyrimidines Found in RNA, not DNA. Found in DNA, not RNA.
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Fig. 10-4, p. 293 Purines Found in DNA and RNA.
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Tautomeric Shifts Purines and pyrimidines may undergo transformation between keto- (lactam) and enol- (lactim) forms, called tautomerization. Tautomerization is necessary to explain Watson-Crick type base pairing.
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Fig. 10-6, p. 293
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Fig. 10-7, p. 293
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Absorption of uv light Purines and pyrimidines, and compounds containing them, typically absorb ultraviolet light at around 260 nm. This can be useful as a quantitative measure of concentration.
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Fig. 10-8a, p. 294 uv Absorption
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Nucleosides A nucleoside = Base + sugar In the case of ribonucleosides, the sugar is D- ribose. In the case of deoxyribonucleosides, the sugar is D-2deoxy-ribose. The pentoses are in the furanose configuration. The glycoside bond linking the sugar and the base is always β . Names end in –idine (pyrimidines) or -osine (purines).
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Fig. 10-10, p. 295 Nucleosides
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Besides its role as a building block for nucleic acids, adenosine has an extracellular hormonal role. It causes vasodilation, for example. Interestingly, the drug caffeine inhibits the combination of adenosine with its extracellular neuronal receptor. Higher levels of adenosine characterize wakefulness, lower levels, sleep.
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This note was uploaded on 01/27/2010 for the course MCB 450 taught by Professor Mintel during the Fall '07 term at University of Illinois at Urbana–Champaign.

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mcb450-10f09 - Chapter 10 Nucleotides and Nucleic Acids...

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