mcb104 handout week 12

mcb104 handout week 12 - T RANSPOSONS and REPETITAVE DNA...

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TRANSPOSONS and REPETITAVE DNA The human genome is highly repetitive. A major source of this repetitive sequence is due to Transposable Elements (Transposons). Transposon : Mobile DNA (genetic) element flanked by terminal repeats. Often transposons contain genes encoding transposition (jumping around in the genome) function. General mechanism: Staggered cuts are made in the DNA The transposable element inserts The staggered cuts leaves short single, stranded DNA that polymerase fills in, resulting in flanking repeats. Two Major Classes of Transposons o DNA Transposons: Transpose directly as DNA o Retrotransposons: Transpose through an RNA intermediate. The retrotransposon is transcribed to RNA then is reverse transcribed back into DNA, which is inserted at the target site. Long-Interspersed Elements (LINEs) Short-Interspersed Elements (SINEs) ex. Alu elements LTR Transposons Transposons as Mutagens o Directly Mutagenic Insert into genes, rendering them nonfunctional. Interfere with genes and their regulatory elements, resulting in altered transcription
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This note was uploaded on 01/28/2010 for the course MCB 104 taught by Professor Urnov during the Fall '09 term at Berkeley.

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mcb104 handout week 12 - T RANSPOSONS and REPETITAVE DNA...

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