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Unformatted text preview: MITOSIS and MEIOSIS Different phases of Mitosis: Cohesin: After DNA replication during interphase, sister chromatids must remain associated with each other until anaphase. This is achieved by multiprotein complexes called cohesins, which hold sister chromatids together along the length of the chromosome and particularly at the centromere. There are different cohesion complexes specific to either mitosis or meiosis. In order for chromosomes to separate during anaphase, cohesin must be cleaved. This is achieved by an enzyme called separase. What is different about the loss of sister chromatid cohesion during mieosis compared with mitosis? During meiosis cohesion must be released in a stepwise fashion to allow the 1) separation of homologous chromosomes during the first meiotic division and 2) the separation of sister chromatids during the second meiotic division. (Remember that the during meiosis homologous chromosomes undergo crossing over. As a result, recombined chromosomes require cleavage of cohesin in order for homologous chromosome to...
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