mcb104 handout week 7 - R eceptor - mediated endocytosis is...

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Receptor-mediated endocytosis is a highly regulated mode of cellular import, and is the primary mode of cellular import for large insoluble molecules entering the cell. What are examples of molecules that enter cells via receptor-mediated endocytosis? Clatherin is the coat protein that mediates the invagination and budding of endosomes from the cell surface during receptor- mediated endocytosis. How does the tertiary and quaternary structure of clatherin facilitate this process? CELL SIGNALLING Cells must be able to sense signals from their environment, and respond appropriately. If the signaling molecule is insoluble to the cell membrane, cells need a way to transmit this signal from the outside the cell to the inside the cell: signal transduction Key features of signal transduction: Binding of the signal molecule (ligand) to a receptor triggers a cellular response. The receptor has 3 domains: extracellular, transmembrane, intracellular domains. Binding of the ligand to the extracellular domain of the receptor causes a conformational change of the receptor’s intracellular domain. The conformational change of the receptor triggers a cascade of events that terminate in one or more cellular responses. The signaling cascade has two important features:
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This note was uploaded on 01/28/2010 for the course MCB 104 taught by Professor Urnov during the Fall '09 term at University of California, Berkeley.

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mcb104 handout week 7 - R eceptor - mediated endocytosis is...

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