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newspaper article - The intervention toward Understanding...

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The intervention toward Understanding the role of M-CSF in the development of HIV encephalitis has begun The researchers in the Neurovirology laboratory at Medial School of Temple University have constructed and characterized the riboprobes encoding an M-CSF gene from macaque monkeys. Approximately 40 million people worldwide are infected with human immunodeficiency virus type 1 (HIV-1), which invades the central nervous system and leads initially to cognitive dysfunction and eventually to dementia, a clinical syndrome known as HIV-1-associated dementia (HIV-D). Clinical- pathological investigation of HIV shows that early in the course of HIV-1 infection, the virus penetrates the CNS via the transmission of virus-infected macrophages that in turn trigger a series of neuroinflammatory responses and lead to a complex set of neuropathological alterations, including HIV encephalitis (HIVE). As published in most research studies, HIVE is a devastating condition that commonly displays a systemic
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abnormality in the differentiation of HIV-1-infected monocytes. Many research efforts have been exerted
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