DDS_DrugTransporters_09 - TransporterFamiliesofInterest...

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Transporter Families of Interest in Drug Delivery Human Genome Project Identified over 800 potential transporters >225 solute carriers (SLC families) >50 ATP binding cassette transporters (ABC family) While the pH partition hypothesis (Overton’s rule) has served well to explain drug transport, “most molecules of physiologic or pharmacologic significance are transported into or out of the cells by proteins rather than by a passive solubility into the lipid layer and diffusion through it.” (Al Awqati, 1999)
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Roles of Transporters Endogenous vs. Exogenous Substrates Influx vs. Efflux Absorptive (into blood or in the direction of) Secretory (out of blood or an organ, e.g. into bile, urine, gut lumen)
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Solute Carrier Family Amino Acid Peptide Organic Cation Organic Anion Nucleoside PEPT1
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Mechanisms of Transport http://highered.mcgraw hill.com/olcweb/cgi/pluginpop.cgi?it=swf::535::535::/sites/dl/free/0072437316/120068/bio04.swf::Cotransport
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This note was uploaded on 01/28/2010 for the course CHEM 130 taught by Professor Kia during the Spring '09 term at Abraham Baldwin Agricultural College.

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DDS_DrugTransporters_09 - TransporterFamiliesofInterest...

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