Bis102_02MT2BlueKey

Bis102_02MT2BlueKey - Name Blue Key Last, First BIS102-02,...

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Name Blue Key BIS102-02, Spring '09, Page 1 of 7 Last, First C. S. Gasser BioSci 102-03 May. 19, 2009, Second Midterm Instructions: There are sevn pages in this exam including the cover sheet, please count them before you start to make sure all are present. Write your name on each page of the exam. Write your answers in the space provided below each question. If you need more space use the back of the page and indicate clearly that you have continued your answer on the back. Do not use additional paper. For calculation problems a clear line of calculations leading to your final answer must be shown to obtain full credit. Use the following pK a values for the exam. Amino Acid α -NH 2 α -COOH R-group log 1.0 = 0.00 Ala, Gly, Ile, Leu, Val 9.7 2.3 log 1.5 = 0.18 Asn, Gln 9.0 2.1 log 2.0 = 0.30 Met, Ser, Trp 9.3 2.3 log 2.5 = 0.40 Phe 9.1 1.8 log 3.0 = 0.48 Pro 10.6 2.0 log 3.5 = 0.54 Thr 10.4 2.6 log 4.0 = 0.60 Asp 9.8 2.1 3.9 log 4.5 = 0.65 Glu 9.7 2.2 4.2 log 5.0 = 0.70 His 9.2 1.8 6.0 log 5.5 = 0.74 Cys 10.8 1.8 8.3 log 6.0 = 0.78 Tyr, Lys 9.1 2.2 10.0 log 6.5 = 0.81 Arg 9.0 2.2 12.5 log 7.0 = 0.85 log 7.5 = 0.88 Question Value Score log 8.0 = 0.90 1 12 log 8.5 = 0.93 2 10 log 9.0 = 0.95 3 18 log 9.5 = 0.98 4 18 log 10.0 = 1.00 5 15 6 15 R = 8.3 X 10 -3 kJ/°mol 7 26 25°C = 298K 8 6 9 15 10 15 Total 150
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Name Blue Key BIS102-02, Spring ‘09, Page 2 of 7 Last, First C. S. Gasser 1. For each of the following pairs of fatty acids circle the one in each pair that will have the lower melting point (3 pts. each). a) 20:1 Δ 9 20:2 Δ 9,12 b) 20:0 c) stearic acid d) 18:2 Δ 9,12 2. ß-thalassemia is a heritable disease that can lead to too low a level of functional ß-globin in the blood. As a result, patients with ß-thalassemia are anemic and their blood has low oxygen carrying capacity. One treatment that has been proposed for such patients is to try to reactivate their γ -globin genes so that γ -globin (normally present only in fetal hemoglobin (HbF)) could replace the defective ß-globin subunits in a significant fraction of the blood. Assuming that such a treatment is so effective that all of the ß-globin in an adult patient is replaced by γ -globin (so that the patient’s blood contains only HbF), answer the following questions. a) (6) The curve below is the oxygen saturation curve for normal adult human hemoglobin. On the graph draw an approximation of the curve that you would expect for the hemoglobin from the patient treated as described above. (higher affinity for O 2 , therefore always above normal Hb curve) (Fraction Saturation) 0 1.0 pO (mm Hg) 2 0 200 Y b) (4) At a given set of conditions and concentration of bisphosphoglycerate (BPG) would you expect normal Hb or the HbF of the treated patient to have more BPG bound to it? Explain very briefly.
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This note was uploaded on 01/29/2010 for the course BIS 102 taught by Professor Hilt during the Winter '08 term at UC Davis.

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Bis102_02MT2BlueKey - Name Blue Key Last, First BIS102-02,...

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