Lecture #2 1-15 -...

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Unformatted text preview: !"#$%&"'()'*+$"&,'-./#.0+1"/$' 2/$"&+#3./4,'56' 7"8'9./#"5$4' •  Properties of WATER are crucial to understanding the properties (structural and functional) of biomolecules because the biological milieu is primarily aqueous — water is the solvent for most biomolecules. ! •  NONCOVALENT INTERACTIONS (hydrogen bonds, ionic interactions, van der Waals interactions, and "hydrophobic interactions") are individually much weaker than covalent bonds, but are absolutely crucial to the structure and function of biomolecules.! •  Most biomolecules have functional groups that are weak acids or bases, and the ionization properties of those groups are crucial to the structures and functions of the molecules; the PH determines the state of ionization of biomolecular weak acids and bases. ! •  Biological systems, intracellular and extracellular, are BUFFERED. ! !"+&/:/;'<=>"#30"4' •  Describe the properties of H2O: its polarity, hydrogen bonding capabilities, solvent properties, and ionization properties.! Explain the features of 4 types of noncovalent interactions (hydrogen bonds, ionic interaction, van der Waals interactions, and hydrophobic interactions), including the effect of solvent polarity and of distance on those interactions. Be able to identify non covalent interactions on a figure! Why hydrogen bonds, hydrophobic interactions are important for biomolecules! What are the properties of amphipathic molecules! Relate the state of protonation of a weak acid to its pKa and the pH of its environment. Be able to interpret and sketch a pH titration curve (dominant form when pH < pKa, when pH=pKa and when pH > pKa! Know and use the Henderson-Hasselbalch equation to estimate the percentage of charged molecules in a solution! Describe the ionization properties of phosphate and what makes it a good buffer in the physiological pH range! •  •  •  •  •  •  ?:.#@"A:4$&8)'&"+#3./4' +/B':/$"&+#3./4'+$'+' /%A="&'.C'B:D"&"/$'4#+1"4'' *+$"&':4':A5.&$+/$'C.&'1:C"' !"#$%&"'()*+%&",#$-.("&/(01"-*()/2$&$.#+"#$%& !!!"#$%$"&'( Phoenix Mars Mission !"#$%&!"#$%&!'#(!#!)%"!*+,-*%!.&/.%&$,%(!0/1.#&%2!$/!/$'%&!3,-*,2( $'#$!1#4%!,$!%((%+$,#3!)/&!3,)%5!678!9#$%&!&%1#,+(!3,-*,2!/:%&!#! ",2%!$%1.%&#$*&%!&#+;%<!.%&1,$$,+;!3,)%!$/!(*&:,:%!,+!03,1#$%! #+2!"%#$'%&!0'#+;%(5!6=8!>+!#+!/../(,$%!(%+(%<!3,-*,2!"#$%&! '#(!#!',;'!0#.#0,$?!$/!'/32!%+%&;?<!1/2%&#$,+;!"%#$'%&!#+2! 03,1#$%5!6@8!A+3,4%!#31/($!#33!/$'%&!1/3%0*3%(<!"#$%&!!/#$(! ! "'%+!,$!)&%%B%(5!C',(!,+(*3#$%(!$'%!"#$%&!D%3/"<!"',0'!&%1#,+(! 3,-*,2!#+2!(*../&$(!3,)%555!!!! 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Lecture #2 1-15 -...

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