Glucocorticoids webnotes

Glucocorticoids webnotes - Glucocorticoids PSIO467/MCB467...

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1 Glucocorticoids PSIO467/MCB467 Session #25 Porterfield Chapter pp 137-139; 142- 152 Patricia B. Hoyer, PhD www.physiology.arizona.edu/PSIO467/
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2 Objectives: Glucocorticoids 1. Identify the functional zones of the adrenal gland, specify hormones produced in the cortex. 2. Appreciate the enzymatic steps involved in steroidogenesis in the adrenal cortex, along with cellular specificity involved in glucocorticoid versus mineralocorticoid production. 3. Compare the properties of cortisol and aldosterone in circulation as reagards serum binding proteins, half-life and concentrations. 4. Distinguish the physiological versus pharmacological effects of glucocorticoids. 5. Diagram the hypothalamic-pituitary-adrenal feedback loop of regulation and indicate physiological factors that impact this loop. 6. Describe the role of cortisol in metabolism. 7. List symptoms/manifestations of Cushing’s Syndrome explaining the reason for each. 8. List the symptoms/manifestations of Addison’s Disease, explaining the reason for hyperpigmentation.
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3 Overview ± Adrenal cortex - long term protection against stress – Hormones - corticosteroids • Mineralocorticoids / salt balance (required for life) • Glucocorticoids / fuel metabolism and response to injury • Androgens ± Cortisol - human glucocorticoid – Physiological effects – Pharmacological effects
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4 Outline ± Anatomy ± Steroidogenesis ± Adrenal Steroids in Blood ± Target Tissues and Physiological Effects ± Regulation of Release ± Role of Cortisol in Metabolism ± Hypersecretion – Cushing’s Syndrome ± Hyposecretion – Addison’s Disease
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5 Anatomy of the Adrenal Cortex Mineralo- corticoids Gluco- Corticoids Androgens Catecholamines
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6 Synthesis of cortical hormones - Steroidogenesis ± Enzymatic conversion of cholesterol to hormone ± Specificity of product – Dependent on enzymes present (expressed) ± Zona glomerulosa (plus 18 hydroxylase, +18OH, minus 17 hydroxylase, -17OH) – Mineralocorticoids = Aldosterone ( required for life ) ± – Glucocorticoids = Cortisol – Androgens = DHEA, androstenedione
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7 SCC z. glomerulosa + 18OH z. fasciculata z. reticularis Puberty Menopause Side Chain Clevage Angiotensin II ACTH
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This note was uploaded on 01/30/2010 for the course PSIO 467 taught by Professor Henriksen during the Fall '08 term at University of Arizona- Tucson.

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Glucocorticoids webnotes - Glucocorticoids PSIO467/MCB467...

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