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SNS webnotes - Sympathetic Nervous System PSIO 467/MCB467...

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1 Sympathetic Nervous System PSIO 467/MCB467 Session #26 Porterfield Chapter pp 131-137 Patricia B. Hoyer, PhD www.physiology.arizona.edu/PSIO467/
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2 Objectives: Sympathetic Nervous System 1. Review the location of the medulla within the adrenal gland. 2. Discuss key features that make the sympathetic nervous system such a rapid responder. 3. Distinguish epinephrine and norepinephrine as regards site of production and circulating levels. 4. Compare and contrast the components of the anatomy of the sympathoadrenal and sympathetic nervous systems and identify the neuroendocrine cells in this system. 5. Diagram key components of catecholamine synthesis in the chromaffin cell. 6. Differentiate adrenergic receptor types and some of their generalized physiological responses. 7. Identify physiological stimuli that activate the sympathetic response (fight or flight). 8. List the major physiological events activated in the sympathetic response. 9. Explain how epinephrine elicits a selective response in regulating glucose metabolism. 10. Describe how α and β receptors work together to regulate cardiovascular function and urinary retention in the bladder. 11. Discuss the pathophysiology of pheochromocytoma.
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3 Overview ± Sympathetic Nervous System – Adrenergic branch of autonomic nervous system First line of defense in responding to stress – Two branches • SNS - preganglionic cholinergic nerve endings synapse with postganglionic adrenergic neurons • Sympthoadrenal System - preganglionic cholinergic nerve endings synapse with postganglionic chromaffin cells (located in adrenal medulla).
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4 Overview cont. ± Sympathetic response – extremely rapidly activated – responds to wide variety of stressors – uniquely tailored • individual components of both branches can be recruited singly or in any combination
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5 Outline ± Anatomy ± Catecholamines ± Adrenal Medulla and Sympathetic Nervous System ± Catecholamine Synthesis ± Adrenergic Receptor Subtypes ± Regulation of Release ± Physiological Effects ± Pathophysiology ± Comparison – Sympathoadrenal and Sympathetic Nervous System
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6 Anatomy of the Adrenals Mineralo- corticoids Gluco- Corticoids Androgens Catecholamines Long term response, mesoderm Short term response, neural crest
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7 Catecholamines ± Epinehprine and Norepinephrine ±
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This note was uploaded on 01/30/2010 for the course PSIO 467 taught by Professor Henriksen during the Fall '08 term at Arizona.

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SNS webnotes - Sympathetic Nervous System PSIO 467/MCB467...

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