Motifs - Catalysis SOD – Recognition Antibodies •...

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BIBC 100
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Motif Simple combination of secondary structure elements with specific geometric array Helix-loop-helix β -loop- β β -Hairpin β - α - β Helical Bundles Very frequent in parallel β- Sheets of proteins
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Topological Diagrams Domain – a unit, a polypeptide that independently folds into tertiary structure α / β - most frequent of regular protein structure Different sequence functions
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Closed Barrel 8+8 Loops at C-end of β -sheet Open Twisted Sheet Variable Crevice at C- end of β - Strand opposite of β - Sheet Parallel β-Strands α / β Active site: formed by functional residues provided by the loop regions that connect C-end of β - with the N-end of α Active Site
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β -Barrel Antiparallel β - Strands Functions: Binding - Retinol binding protein Transport - Porin
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Unformatted text preview: Catalysis - SOD – Recognition - Antibodies • Structures: (motifs) – Up and down (Cavity)-Regular – Greek key – Jelly roll Distorted Fold: β-helix – wide helix with 2 or β-strands/turn Barrels Influenza Virus (RNA) • Membrane Enveloped • NA – Neuraminidase (Tetramer) • HA – Hemaglutinin (Trimer) • Example of Molecular Parntership – HA Binds to sialic acid on surface of suceptible cells endocytosis RNA release – NA cleaves sialic acid, assists in releasing progeny virions NA • 1600 a.a. • Four subunits • 24 β- strands/subunits (superbarrel) • 6 motifs: 4 β-strands per motif (up and down) • Active Site: formed by loops at one end of the super barrel – Wide, funnel-shaped...
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This note was uploaded on 01/30/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Winter '09 term at UCSD.

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Motifs - Catalysis SOD – Recognition Antibodies •...

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