Motifs - Catalysis - SOD Recognition - Antibodies...

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BIBC 100
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Motif Simple combination of secondary structure elements with specific geometric array Helix-loop-helix β -loop- β β -Hairpin β - α - β Helical Bundles Very frequent in parallel β- Sheets of proteins
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Topological Diagrams Domain – a unit, a polypeptide that independently folds into tertiary structure α / β - most frequent of regular protein structure Different sequence functions
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Closed Barrel 8+8 Loops at C-end of β -sheet Open Twisted Sheet Variable Crevice at C- end of β - Strand opposite of β - Sheet Parallel β-Strands α / β Active site: formed by functional residues provided by the loop regions that connect C-end of β - with the N-end of α Active Site
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β -Barrel Antiparallel β - Strands Functions: Binding - Retinol binding protein Transport - Porin
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Unformatted text preview: Catalysis - SOD Recognition - Antibodies Structures: (motifs) Up and down (Cavity)-Regular Greek key Jelly roll Distorted Fold: -helix wide helix with 2 or -strands/turn Barrels Influenza Virus (RNA) Membrane Enveloped NA Neuraminidase (Tetramer) HA Hemaglutinin (Trimer) Example of Molecular Parntership HA Binds to sialic acid on surface of suceptible cells endocytosis RNA release NA cleaves sialic acid, assists in releasing progeny virions NA 1600 a.a. Four subunits 24 - strands/subunits (superbarrel) 6 motifs: 4 -strands per motif (up and down) Active Site: formed by loops at one end of the super barrel Wide, funnel-shaped...
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Motifs - Catalysis - SOD Recognition - Antibodies...

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