WaterandBasics

WaterandBasics - BIBC 100 Structural Biochemistry...

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Structural Biochemistry BIBC 100
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Papers- Dialogue with Scientists Questions: Why? How? What? So What?
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Dialogue Structure – to explain function Knowledge Food Molecular Medicine Farming Fine Chemicals(drugs) Diagnosis / Therapy
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Dimensions (1Å = 10 -10 m) Red Blood Cell 10 -5 10 10 5 Bacterium 10 -6 1 10 4 Macro- molecule [protein] 10 -8 10 2 Small molecule [glucose] 10 -9 10 Limit of light microscopy High resolution EM m µm Å C-C Bond 10 -10 1.5 X-rays/NMR
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Today Interactions in Biology Uniqueness of Water Protein primary structure: 20 amino acid repertoire The peptide unit Proteins have unique sequence specified by genes Sequence determines 3-D structure, and function
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The Bread and Butter of the Course Structure Basis of Molecular Function Structure Intervention Control Function
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Why Structural Biology? Form and Function Structure to understand Vital Function How?
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WaterandBasics - BIBC 100 Structural Biochemistry...

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