3 - TA: Christine Feng hufeng@ucsd.edu Section: Mon 4-5...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
TA: Christine Feng hufeng@ucsd.edu Section: Mon 4-5 Center 205 OH: Wed 11-12 Geisel S&E This Week in Lecture: Dogma of Course: sequence structure function Other β structures DNA sequence & structure Problem of Protein Folding Ch 5, 7 β Structures Can function in binding, transport, catalysis, recognition Up & down, Greek key, Jelly Roll β barrel o Amino acid sequence reflects structure o Alternating hydrophilic/hydrophobic amino acids to expose polar/charged residues and form hydrophobic core o Active site is hydrophobic (Tyr-Met-Phe-Phe-Phe-Phe-Phe) to accommodate for the hydrophobic part of retinol (fig 5.4 ) Neuraminidase – example of up & down β sheet o 4-antiparallel-stranded sheets arranged in a 6-bladed propeller o Neuraminidase is a tetramer – 4 identical polypeptide chains totally 1600 AA, each folded into a propeller-like superbarrel (fig 5.8 ) o Oligomer : a protein that is composed of various subunits
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 2

3 - TA: Christine Feng hufeng@ucsd.edu Section: Mon 4-5...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online