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lecture 1-2 - Lecture 2 Interactions between protein and...

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Lecture 2 Interactions between protein and environment. Tetrahedral. Carbon and 4 hydrogens- 90 degree, water does not fit with 3 electron pairs in oxygen, but 2 hydrogens are close. Small molecules: extra electron pairs make water very dipolar molecule. Positive charge from 2 hydrogen and negative like from oxygen. They are dipolar character. And the unique arrangement of charge likecenters in water facilitates arrangement where hydrogen atoms associated with 1 water molecule, but are shared between 2 water molecules. Hydrogen binding, 2 electron negative centers with positive hydrogen between them, arrangement is close to linear as possible. Formally it is difficult to say who owns hydrogen. Water is forming hydrogen structures, molecular model of ice. Extreme version, most important it is reasonably stable. Water molecule exists over time. Important concept, even fluid liquid water has significant fraction of water molecules in ice like structures. It is estimated ¼ of water molecules are in highly structured form. Those structures do not exist in fluid over
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