lecture 4.doc - In the universe entropy increases. Bio...

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In the universe entropy increases. Bio system defines universe as long as they exist. Equilibrium is a stable state. May be stable for a period of time. But now may be equilibrium condition. Protein may achieve their steady state--- may put heat to break water structures. In classical thermo terms---the ultimate state of protein—when all peptides broken, free amino acids. There is large activation barrier. Order and disorder of proteins and relationship to solvent. The order or disorder of solvent dominates the 3d structure of proteins. But there are additional forces (van der waals). Approaches one can adopt to figure primary structure of protein in polypeptide chain. How can we selectively cleave the chain by specific reaction. Once we figure fragments and sequence. Overlapping sequence technique. It does not matter whether we will be able to sequence the chain, but develop systematic approaches to determine the sequence of info bits. Putting physical signs and symptoms. Ordering facts in order to tell a story. 1)
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lecture 4.doc - In the universe entropy increases. Bio...

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