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BISC 330 Spring 2010 Lecture 7

BISC 330 Spring 2010 Lecture 7 - BISC330L:Biochemistry...

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BISC 330L:  Biochemistry Spring Semester 2010 USC Lecture:  Wed, 27 January 2010 1.More Chapter 2 material… Tertiary Structure Quaternary Structure
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Tertiary Structure Shows conformation of the whole polypeptide Stabilized by noncovalent bonds Can be studied by X-ray crystallography Proteins can be:  fibrous (long and extended)  globular (blobs) Ras
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Myoglobin is a good example Kendrew; Cambridge University, 1957 First globular protein whose tertiary structure  was determined Primarily alpha-helical in structure (75%);  connected with loops and turns
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Example of  αβ  Barrel Tertiary Structure Triosphosphate Isomerase (Fig, 16.4)
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Examples of Protein Tertiary Structures Ferritin (mainly  α ) F.A.Binding Protein (mainly  β ) Myoglobin (mainly  α ) Green  Fluorescent Protein (mainly  β ) [Ser-Tyr-Gly]
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Unique distribution of amino  acids Yellow  = hydrophobic Blue  = hydrophilic White = other
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Membrane proteins are  unique Porins Reverse distribution  of amino acids
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Motifs v. Domains
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