Week 3 - Abbreviated Answer Key

Week 3 - Abbreviated Answer Key - BIPN 100 Dr. Fortes Chris...

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BIPN 100 Chris Childers Dr. Fortes Winter 2010 Test Questions 1. You are testing the effect of the drug digoxin, an inhibitor of Na/K pumps, on an axon. a. Write the reaction catalyzed by Na/K pumps, including all the substrates, products, and their stoichiometries: 3Na+(in) + 2K+(out) + ATP + H2O 3Na+(out) + 2K+(in) + ADP + Pi b. Before addition of digoxin the resting membrane potential is -70 mV and a single stimulus generates a normal action potential. Predict what will happen to the resting potential (depolarized, hyperpolarized, or no change) and to the response when you give a single stimulus immediately after adding a maximum dose of digoxin (increased or decreased amplitude of spike, or no change, or no response) and briefly explain why: Resting potential: no change because ion leaks are slow and the concentration gradients are not affected Action potential: no change, because the relatively small number of ions that will flow during a single action potential will not change significantly the concentrations
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This note was uploaded on 01/31/2010 for the course BILD BIPN 100 taught by Professor French during the Winter '08 term at UCSD.

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Week 3 - Abbreviated Answer Key - BIPN 100 Dr. Fortes Chris...

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