Handout 30

Handout 30 - Daniel Hans OH: Monday 3-4:00PM Caf Roma I....

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Daniel Hans OH: Monday 3-4:00PM Café Roma Handout 3 I. 2 Major  types  of postsynaptic  receptors     a. Ionotropic -receptor themselves are the ion channel b. Metabotropic -acts through 2 nd messenger system i. G-protein  coupled  receptors 1. Off state: G protein has Gα, Gβ, and Gα sections. Gα section is bound to GDP. 2. On state: Ligand binds conformational change GDP exchanges with GTP now activated alter enzyme activity which turns on 2 nd messengers usually activating protein kinases 3. Termination: intrinsic GTPase activity- hydrolyze GTP to GDP. Slow. a. What would happen if you inhibit GTPase? i. G protein would continue to activate and would have no method of turning off. Too much stimulation. . ii. Main  2 nd  Messengers 1. cAMP(Cyclic AMP)-activates protein kinases 2. Ca2+-alters enzyme activity 3. PIP2 makes 2 messengers a. IP3-increases intracellular Ca by opening Ca Channels b. DAG-activates protein kinases II. Ligands  involved  in cell’s  long- distance  communication     a. Neurocrines -Electrical signal travels down neuron, and is translated to a chemical signal. i. Neurotransmitters -chemicals secreted by neurons and go to target cell ii. Neuromodulators -acts more slowly as an autocrine or paracrine signal iii. Neurohormones -hormones released by neurons into blood b. Hormones -secreted by endocrine glands or cells into blood III. Neurotransmitters NT Type Receptor Locations Effects Agonists/Anta gonists Chemical Acetylch oline   (ACh) nAChR (Ionotropic ) Skeletal   muscles,  ANS,   CNS Excitatory : Opens N a+/K+  channel   Muscle contraction, interneuron signaling Agonist - Nicotine Antagonist – Bungarotoxin mAChR (metabot ropic) Smooth/cardia c muscle, glands ( Parasympat Inhibitory : Heart ( opens  K+chnls ) Excitatory: Glands, GI, bladder, Antagonist - Atropine
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Daniel Hans OH: Monday 3-4:00PM Café Roma hetic Input) CNS bronchioles (via vagus nerves) Amines Norepin ephrine (NE) & Epineph rine (E) Made from Tyrosine Main NTs for sympathe tic nervous system (Catechol amine) Adrenergi c α-1 (NE > E) (metabotr opic) Blood vessels,
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This note was uploaded on 01/31/2010 for the course BILD BIPN100 taught by Professor Fortes during the Spring '10 term at UCSD.

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Handout 30 - Daniel Hans OH: Monday 3-4:00PM Caf Roma I....

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