This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: base catalysis. Why isnt glycine among those listed? 8. If a protonated His residue acts as the proton donor in an acid-catalyzed enzymetic reaction, what happens to the enzymes activity as the pH increases to a value that exceeds the pK R of that residue? 9. The pK values of two essential catalytic residues in RNase A are 5.4 and 6.4. Which corresponds to His 12 and which to His 119? 10. What is the difference between nucleophilic catalysis and general base catalysis? 11. A good covalent catalyst is highly nucleophilic and can form a good leaving group. What structural properties support these seemingly opposite characteristics? 12. Classify each of the following groups as an electrophile or nucleophile: a) amine b) carbonyl c) cationic imine d) hydroxyl e) imidazole 13. What is the role of Zn 2+ in carbonic anhydrase? 14. How hoes lysozyme destroys bacterial cell walls?...
View Full Document