ProblemSet4 - Practice Problem Set # 4 114A; 2006 1.What is...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Practice Problem Set # 4 114A; 2006 1.What is the effect of each of the following treatments on the oxygen affinity of hemoglobin A in vitro? a) Increase in pH from 7.2 to 7.4 b) Increase in BPG concentration from 0.2 mM to 0.8 mM c) Dissociation of a2b2 into monomer subunits d) Increase in pCO2 from 10 to 100 torrs 2. Some mutations in a hemoglobulin gene affect Hb A (adult hemoglobulin) and Hb F (fetal hemoglobin), whereas others affect only one of them. Why? 3. Describe the molecular feature of hemoglobin S (sickle cell hemoglobin). Explain the consequence of Hb S when oxygenated. 4. a. What can we conclude about the oxygen-binding sites in Hb based on observing a sigmoid binding curve. b. Apparently the binding of oxygen to Hb is affected by the pH. What is this effect called? e. Draw a curve for oxygen binding to Myoglobin, knowing that the p50 for that interaction is equal to 3 torr.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Use the following to answer questions 5-14: A) tertiary structure B) keratin C) molecular chaperone
Background image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 2

ProblemSet4 - Practice Problem Set # 4 114A; 2006 1.What is...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online