J.%20DriftCh.10 - Population structure and genetic drift...

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1 Population structure and genetic drift Outline of lecture: • Genetic drift – Coalescence, random Fuctuations in allele frequencies, effective population size • Neutral Theory of Molecular Evolution • Gene Fow and genetic drift Population structure What factors can drive the genetic differentiation of populations? What factors can prevent differentiation? Population structure Selection Drift Migration Genetic drift Random Fuctuation in allele frequencies from one generation to the next. Why? Coalescence Coalescence N = 5 N = 10 1 generation = 0.2 2 generations = 0.16 3 generations = 0.128 1 generation = 0.1 2 generations = 0.091 3 generations = 0.081 (1 - (1/ N )) G- 1 x 1/ N
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2 Random fuctuations in allele Frequencies Genetic driFt - eFFect oF population size 100 individuals, p = 0.5 Genetic driFt - eFFect oF population size 25 individuals, p = 0.5 Random fuctuations in allele Frequencies • The probability oF ±xation oF an allele is equal to the Frequency oF that allele. p=
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This note was uploaded on 01/31/2010 for the course EEB 390 taught by Professor Staff during the Winter '08 term at University of Michigan.

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J.%20DriftCh.10 - Population structure and genetic drift...

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