medch403-1993 - .— _ _—--I- ____.__ 441-502 1 l 8 (20)...

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Unformatted text preview: .— _ _—--I- ____.__ 441-502 1 l 8 (20) ., Egamm‘m I n .92 A; (27) mm; 3, 1993 III; L (21)- IV- __-.2____ (32) 15 .e neat] . Confine our answers to the s m rov-ided. (20 points) Do both parts. Compare and contrast the expected pharmacoiogicel activity and potential therapeutic use: of the following set! of three compounds. Indicate what difference: may be expand and why. Include the phenineoiogical activity that is being compared and contrasted; Where indicated give a chemical ottoman. Expllin in complete sentences limited to the space provided. . far, I? 4‘ 0H 0 at f .U-i‘ I. r, t’ J I _ improteren‘ol he—{ioi- ' '°"‘ O‘Cfla-CHCHz-NHCHpra (N-iPr-norepinephrine) 3 9H ' 0% (given-om) cmcnz—Nnctcngm ‘llul {pd to 7*. On. 7‘; _ .1 I _ 930.9%) '3‘" ‘i 1 "1h: «cit-"4' ah???“ “£1, 0H 17'L_""'_ 1511'th Q r ,., , ' . " ‘ Ij'ol'OVTiLTi" “L Sufi-1,1 bog-m 3L _ - . (IL-l, fr -;_1{Y‘ pr-RLTQJ- (flacif'l—ntk} ‘ A” ‘ *ilkdljpu’. Err-ll: '- H" (h ["fl'i‘.“ [‘ '- ‘ L ‘ L IAN: '5HL'HUI“. I '1'. Mil-11414;? if 1 L531, '- t LII: ,JLN) 19%)!) MALE L7, (.24., giw‘ (Jr Ora; l I .. ._ , . l ._ _ _ '~.-*;.l"._-.‘L4L‘L_ -- I“? “' M er-‘r W- m méé‘i'uf‘i .43; I? no 'l’H'N r‘ " " F;‘.r5_br"".'>;L’ - . w J 'rr. .: ‘n_ r (flail!) 0rd,“) L!!! 31"?) I“ ’.",’l_r—-.'_.LL' (-2) N;CH3 H30§§,CH3 ammo (give structm'e) :- BI" I 'l /{s. a“ I. a“ $112011 Z q (51120}! ’ \ ‘[ H o — -Ph — ' '--—~, '. ' «I; on I o—E—cn n: L; {I J. I" , s _ I 3—1 \ 1 cm-sw —. , ' a: Tmfl’w‘“ Mm ‘ “‘3' fl'd"£b( “U: 3‘!“qu LOU-L iril-agcxufi- .L"-i“-J ' 1.); l' l“ 1,.) 3 I (“r .U“ L¥1\f'rl._J-- .9. . QM: Had-11M. ind Nu !L C»: Syd-pomp." ,,‘) ‘3:- m, 003‘” “MW chéLJi—obtoof». Mik J up." ‘.. ‘ . 1,15 “ 1 Udficr pacth 9W” 16H . mm“? S'IJ PICA : 5,; caching a. In nicotine. which nicragen has which“ 1314:? Is cannin- solubl. 1-. water a: pH 4.5: «by “31:3; :29?" 9‘ “KAme 13. um: 13 tho “zucchini: of the chiral carbon? €- ‘% c. um- : detail“! chemical nuchnnin for this anabolic pron-n. air—Q- .GNNAOQNMDH B. (8) Eric: I dauiled chain]. process for the can-union of non to_ cpinnphrinn. Incluén : dual“! chaicalqnciunhl ta; ch. conversion at DOPA hi, ‘. a to Darwin... P”. a . = "I (a) 4' mu 4: ..~ H ' ",4? A .9? fl :uww I _.Z"_‘__ .. 0 fl. /-.,'ne :3 indicated . J Il-i’IF v-'J.../. -- | ' 110 Q zcxzwz wail-:2 tnvlrc. - dark s-sy’r: rim 3,9,1 :4 .1:- or 4‘Ir3‘:'me.. («mus -. therapeuci: use: 3:22: 3e3-Ezu ...«... —--....-._ _. _ :'.-‘.a:'1.y indicate vita: iif:e:.-.'.".:es :33 be “Mend. being “:3 _. Ache aczioniusc of both cczfiounds. Ci‘ke reason: :5 explai: . and. I L-"'_}.-.‘r'rJzz’r:-L.:,L-_1"‘ Hafil-j-Hllf-Pq" [Crag-n1 :_-‘.‘('l‘.'( l +Cs‘zz'.e.$t.al URL. CaCILIU't up" ‘ I '-'.|:/_l.' ..p \ I G H Lx. OH / “ ca Dr M}: flue mam-n; {rum-u.sz and a». low. . A!“ (DU-“U— 052:3! :Jsrzhc-znoé 2‘: II ‘ ‘ . . ' I ' f . - '.-.<.. ,u' ’f' ' .1. ram 0 'F anal-m F‘ ‘ '31'-C--*.‘..‘a.!..'..."_, t“_: {*ng Lg-‘II': l '- ‘1‘.1.I'.3(: I; .‘L-Z-'. ' : Tait-'1'; If 'n/ .L. - is“! n: 2* f. swarm 'r'a-J ; c. cultidinc (“manner- ‘3- CQ. and HO‘IIC Alta-Lt vol - Stink-1'6 7?fi':¢d. (av? «#247. ' J' '-'-'.:- :f mate-J - " :-:1_ , J — J cpincphrino (structural "' .3. 9A n-l- @Nw'cuj’ U25] .Pgrarflflyb I . OJ" shka gardJ-Z‘Ic. r Shh-aid uh"? 10.: r: 45H!“flfib .11 56.315, - Q5Socan5¢*.5t-5?‘=fi :"(H [601%. 3" 4 ' 77" Lfiifi': C ; I. I. .r' 'L' + {lib-4 V I 1J0 __'__,.--“H__ " ' an" .-.'--' “1),; ';__ .= r“; J L/9 fax—#5 OH OH ’ I 2 0‘CH'?h [bit-Hf] - 5U: t'c‘f r1: 33ng LA. 7: 99w v. .1. (La/v1 32:61.4: 5. Eel-3.x: r1 Mad-A. bah-‘QLM‘ f . LSD - (lyscrgic acid diathylanidn) l l' .and [::::1\\ a (D (:5 ‘k ca—cdoca CHZHEtJ 3: watt: insolublc (pnptidc) crgo: alkaloids c1. farm -_ - I P o - 4| 0 . I" £"..-.r.-!'.:.o1-:.*- 4f?l.I'1PL§/{la. C'J/xcss uaaowrgflu'c ram 3‘» 5" ‘34 of 1132123}??? 1‘ .‘t'yjc A; ...
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This note was uploaded on 01/31/2010 for the course MEDCH 563 taught by Professor Wendell during the Spring '10 term at University of Washington.

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medch403-1993 - .— _ _—--I- ____.__ 441-502 1 l 8 (20)...

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