medch403-1992 - . F—. MedicinglChemlm-ymw I. us) A 1'...

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Unformatted text preview: . F—. MedicinglChemlm-ymw I. us) A 1' Examination ll. (15) ‘ebursry 5.1992 111. ' 5-) (30) w W “1 - («1) TOTAL (100) Write neat] . Confine our answers to the s cc rovided. ' I. (15 points) For each of the following engines, indicate what is s norm! substrate and why this enzyme is important. physiologically} and why is it s possible target for therapeutically useful agents. Explain in 25 wards or less using complete sentences. - com. ‘ - ' - -- '9: NE 1-.- l A Mona-1 “Lima 1C» com- a, 4L Aduml (“my a. E— , . I+ '35 impor‘l'asd' 1n. lflgfil‘llflt'l‘lfig . drflflgic durafmflsm;#mo ’I" " ‘* f"’”””" “*3” WM“— Po'l-M'i-i n+c... adrenal-air. fc-SEMSLS. (fflfftfisg JuM'I‘J'J-H. of ALI-I'M) T ' Cfiolme aeetyl trmsfenss (CAT'S . ' A norms-.- SULBS‘i-r-A‘i-e. 'For CflT 'ns dko‘iu. H 'w wfiw "A “u I+ {5' a. PossiUL fur-3c} éccnmsc. Hair-easel etc-H.035. of CA1" 3,- . .I . , oz mamas Mae-Me . '90“.an IA W 01"“ ink;£;{.}m Hamil Jive. ‘a' Acksé‘“ c-W—r—T—fijf— A newt-1 éuLs-l-ro-ig 4'..- 5'_[;P,xy3m is «rack: new. . If :5 }.n./Ju-ILM+ in “H.1— fvr-mad‘fm of: kuoo'l‘riw— 5419/“; of guy—13" wflzlnaficz Msemsg. '- I'l' is d. P0552“: {at/762‘ (kb'ér'fi'ht If f-lfeaflflmndl. not! 51.. ML gF/ca‘ire. 741' “#014. ,p-n. 2 (15 points} Do either pert e orb. Write e deteiled chemieel meeheniem with humedietee fer the eonvenienee of eoetyieholine to ecetio end choline Atha- ’- , Write e detailed chemical meeheniem with intennedietee _ I (3“ for the eenvereion of norepinephfine'to ' 3 ' . “#“wgtwsx ' ©W= CH5 I. '(30 pointe) Give the etructure ofene compound (no it troupe) that meete the indicated criterie. An expected oxidetive metabolite of dmetidine' lb. The S—enentionm- of e ehirel mu‘eeen'nie egoniee ‘ r 4:43 that he oer-aerate ester " “cede-M- Mali-— '__ . - . O " 6 r...‘ c’ UH“B_ “4)” . - ‘ Q A short eefing depolarizing entegom’et b d. An orally elective flg-edrenefgie egoniet useful ecetylcholine It the myonennl junction in the ire-men: of eethm ' . . g“, 0 0 9 9 I S» -uL. ug—o-‘é- camcoo aid-1L9“: “ ° ._ “a.” flag); ' OH. “0657'!!- )5 A proer of epinephrine useful in the treatment I. An expected eridetive metabolite of etropine ‘ of glaucome 77"--..- 9-4! .I-’) d..."’1_el . ‘ - 3 I ‘(40 pointa) Do part a and any 5 Own Ruining a part.- (at: part: an to he antral-ad). Write omit. acroaa tha fix partathatyoudonotwantgradd. Structural changea between compounds afford compounda with significantly different pharmacological efl'ecu and/or therapeutic nus. For each pair of compounda, indicate what difl'anncca (pharmaaplocical I and!" therapeutic) maybe axpectad‘ and 12th Be aura to indicate what pharmacological activity in being comparedfcdntrasted. Writ: complete antenna limited to the space provided. -a . (10)!!- and S-iaoprqurenoi (Alan draw chemical atru'cturaa of then manfioman.) H», H” H WM I a miss—4mm, w‘fi” .33.. MW. “mafia mat-r3 p“.- . q. ' W5” ‘ ' 'I _ . 3‘18WE'I” ' i ‘6‘” . I; _ Z; “‘ “‘44 d‘u£4¢,&“,wtfué. b "‘2’" ‘5 " CH; ‘—C'—0-_-CHZCH2 é-NMas Br and m—£’*S-Cfig"¢flg§me3 Bl“ Md 5‘..1,M£WW,- ' W. 4’4 7% «a. fin: “WM, 54/4,...” a 4,: .4. ##Hm, a A “I qwxacwmé h an ‘M .1, MWIMW 44...! _ flmzfliifiwm £14 _ - \‘f ' . o 0 Br and a 9“. a ?H O—C—CH-Ph 0234-0341: CH3CHZCHZCHfinch2NM°3 3' and MeaucnzcazcnzcnzcnzcnzNMea 233. , #79414 a MW MWW- 9L memw @‘gm 4/44; , M M - a. - W" (QM)- EffigWfiflr-Ww. - MM“ ~74” we: I - 0A: I l:- RDA ‘nd HEAR] “I _ , H NM. ' h fimm mm Wifmf ‘ CH CHQNH Hfiu/ n 4' "" F142 ' 2 l. \rj': a d NVNH gs _ _ OH; I WEI-W" 9““ Wwfl‘ifl m” #z W3 M f'L’" M 1"” 3”” .W n “W b" 695?? WA.va ‘ . ’ ‘,..fiLM-JQ?LM CH c': H CH3 H a. 4- ..\ 2 — i — and - A - W d- W 0 CH“ rel—J 4- WWW” )- (cuahc c M 1‘1 3.01 “25.1.: I; “mm ...
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medch403-1992 - . F—. MedicinglChemlm-ymw I. us) A 1'...

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