Phcol 402 Exam 1 - Pharmacology 402 Wlnter 2007 Exam 1 Name S lWeMl l*d"W.ll R 8 b P"lO.C.rn Mouknz S.rnY M H*W u Johl l p u n d Multiple Choice(2

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- - - Rl"*d."W.ll Pharmacology 402 Name 8.b -. Mouknz Wlnter 2007 - Exam 1 P."lO.C.rn S.".*.rnY SlWeMl Johl lpund Mu H*W Multiple Choice (2 points each) 1. Which of the following statements concerning the neuromuscular junction is &&e? A. The cell bodies of motor neurons are in the spinal cord. 1 -8. The postsynaptic receptors for acetylcholine at the neuromuscular junction are muscarinic receptors. C. Termination of synaptic transmission is primarily by hydrolysis of acetyicholine. D. Acetylcholine is synthesized from choline and acetyl CoA. 2. Botulinus Toxin can be used to treat various types of involuntary muscle spasms (distonias) because: The toxin is competitive inhibitor of the postsynaptic receptor at the neuromuscular junction. B. The toxin stimulates acetylcholine esterase. <- - . C: The toxin inhibits the synaptic release of acetylcholine. D. The toxin stimulates the synaptic release of acetylcholine. 3. Physostigmine inhibits acetylcholine esterase: By noncovalent and rapidly reversible binding to acetylcholine esterase. B. By forming a phosphorylated enzyme intermediate with acetylcholine esterase. /%:- By carbamylating the active site serine of the acetylcholine esterase. D: By functioning as a partial agonist for acetylcholine esterase and desensitizing it, 4. A major distinction between the parasympathetic and sympathetic nervous systems is: 'A,- The parasympathetic nervous system uses acetylcholine as the neurotransmitter and the sympathetic ,- system only uses norepinephrine. $1 The pre-ganglion fibers of the parasympathetic nervous system originate in the cranial and sacral regions of the spinal cord while the sympathetic preganglion neurons originate in the intermediate spinal cord. fA The parasympathetic system innervates vascular smooth muscle but the sympathetic system does not. fX Activation of the sympathetic nervous system generally reduces cardiac output while the parasympathetic system speeds up heart rate. 5. The adrenal glands release: Epinephrine and acetylcholine B. Epinephrine and dopamine (C3 Epinephrine and Norepinephrine D. None of the above. 6. Parasympathetic activity causes: @ Miosis (pupillary constriction). B. Mydriasis (pupiilary dilation) C. Relaxation of the cilliary muscle D. No effect on the ciliary muscle 7. The neurotransmitter released from preganglionic terminals onto postganglionic terminals in the sympathetic nervous system is: Norepinephrine B. Epinephrine C. Dopamine 4 None of the above C-- Pharmacology 402 -Winter 2007 -Exam 1 -
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8. Which of the following dwgs are muscarinic agonists?
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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Phcol 402 Exam 1 - Pharmacology 402 Wlnter 2007 Exam 1 Name S lWeMl l*d"W.ll R 8 b P"lO.C.rn Mouknz S.rnY M H*W u Johl l p u n d Multiple Choice(2

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