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Pceut532_Final_2001 - PHARMACEUTICS 405 Winter ZED Nam...

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Unformatted text preview: PHARMACEUTICS 405 Winter ZED! Nam: Final Exam Smdent # March I4, 2001 l. (9 pm} Cluck than: apprupfim box. In all cam am tha: Micimlis Marten kinetin Ippljr. Ammunwmusadminmmuphmmnmfimbdowxma scanilugafilhmic pint gnu; «summation mm time is lime: True 3 False HAfiuimnvmusadnfinimflumlhcarflmdfllheplaflmcmmnfimtime maimrmmmlhmmiawdyfithdm True X Full: C.Duringr.:«1:.mssl‘.m.1|lmu:i.1:I.'t'1.I.I'.:it:wr.I._.'IuI-riullsaluliml:il'ifil..".iul:rriram:iatmzuiml1m:"In":|1."arI {ll}: maximum-n mofmctaboiism}, 111: study mt: mnemtmtim achieved is equal to Km Tm: F113: 3 2. (SmJMKkawfimmhubemmminformfimmdhis WehulisMcntcnpumm-sm: va=33flmyday Km: Iflmgfl. ‘ Calculatethudailydusenqnimdmnchiwe; mmmflunoflfimgfl... 11/1: ,JhuJL;C5$—: 35W} in [cm H. § kart (n [fimaft -[- Khan; '- Hfma— fishy TLL 01113 Jim. rctm'rut ['5 HI "13/ “Inf. _" (1Hpu)PCre-:eiv¢d32mtnydnyufpheuyto'mandanhiwedaplmkvclof 4.fimgfL.Whenmedmmdauhl¢dm4Wdty,dnplmmlmlhmmmd :. 1:319.le -. mmmmfiufistwmmevmxmfmflfismflmtm meamhcdp-aphpapu, label theplaundshowulcuintinns). : - C -—E‘L Kit} I“ {$5 1- VM V Ko {:15 Kit/{:5 “Mg/iota LLEMa/L iii-i“ L/aiay {man-La. {Jng [WMjJJL 1-0- ‘I {- (Gina, . Flat to vs 'Ko /{':5 UM'U = i'atmrrt = 530mg fauna, -K a 5L 9_ : W5—E-EEM L =3 Hm: SHEER [L m P {‘HA; "25'11'LHI3 3’ 3 iiiilfll m:$=:mL—- "flfifiiflfiw—firfl: a:%:-.-__---::::=r.::::n':=:::::::::::"..a a-mmw-"n—m: flfi?fifinfiigfifiiflfiififififih"fii :=:::'.::=::::r.=::.1m:=m=m=====g======::==:am=:==a Fuflugm—“E'Ifigwmnnhufi2%2=g =====m=====n==fla=======amm::===:=:::::- H}:- =-.==::=::: g":E-=fi‘=fln.“":_fi.nufifi?-Trfi“-.m “3%) EEEEEEEEEEEfifififiiifiiféfiiiiiiiifififihfim E r. “ll-"LmnluflmmlllIII-Illmlll-IIIIIIIIIIIIIIIII”III-I lull-nun‘IIIIII‘II'IIIII-III[IIIIIIIIIIIIIIIIIIIII-IIIIIIII'IIIIIIIII InlllII—nlmmnllll—II[II“I.III.“III-IllllnnmllllIlllIII- IIIImIIII-umlilull'll-IIIIIIII[IIIIIIIIIIIIIIIIII'IIIIIIIIIIIIIII IIIIIII—‘IIlium!llIIIIIIIIIII-Illllll‘IqullIIII-IIIIIIIIIIIIIII III-“IIIIIIII'IIL'IIIIIIIIIIIIIIII-IlllllfllnumlllmlIllIII-I'll" IllIlIl-IIII-IIIIIILIIIIIIIIIII-IIIIIIIIII“lull-IIImIIIIunIIIIIIII lililmIllquIh‘lulllllllI'll-III.-IIIIIIII-IImIIIIIII'I-llllll. qua. lullnllllllull”En-ullfllllnflllluullllllIInIIII-llm-ll-l “III-IIII-IIII—IM‘IIIIIIIIIIIIIIIIIII'IIIIII.m—IIIIIIIIIIII-lllll “III..."IIIIIIIIIIIIEI"IIII'II.I'mIIIIIIII-"IIIIIII—IIIIIIIIIIII IIIIIIIIIIIIIIIIIIIII-I'E-IIIIII.IIlullIIIlullnlll:lmlllllllllllil IIulIII—III-IIIIIIIIIHIIIII[III-IIIIIIIIIIIIIIIIII III-IIIIIIIIIIII. lull-IIIIIIII'IIIIIII'IIIIIIII-IIIIIIIIIIIIIIIIIIIIIIII-IIIIIIIIIIIIIII III-IlmlllmulllIIIIIIIII.IIII.[III-IllIIIIIIIIIIIIIIIIIIIIIIIIIII III-I'll..-[HI-III.-lulluln‘l"III-Illl'll-IFIIIIIIII‘II-IIIIIIIII-IIII III-I[EllI...llllulIIIIIIIII51‘II"!I!!!It“.1'}l'-;lIn}?!FIIHI'L'II'I'III'IIIIIIIIIIIIIII Illlll-IllIIIIIIlm-Illllllils‘l'hlflllllullIIIIIII-kal:IIIIIII‘IIIIIIIIII IIIIIIIIIIIIII'IIIIIIIIIIIIIIIIIIL‘IIIIIIIIIIIIll-.III'JIIIIIIIIIIIIIIIIIII I'll-IIIIIIIIIIIIIIIIllIl'IIIIIIII-“ninlllIll-InllnllllIllllIl‘IlllI . 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' lI-IIIIIIIIIIflIIIIIIIIIII-IIIIIIIIIHIKIIIIIIIIInIl-I-IIIIIIII-III..- IIIIIIIIIIIIIIIIIIIIIIIII.-Ill-IIIIIIIIIIIIIIIIIIIII‘ll-II“!lull-III: Ill-lI-I—IIIIIIIIIIIIIII.-IIIIIIII]IIIllfill.[I'll-IIIIIIIIIIIIIIIIIII III-IIIIIIIIIIIIIIIIIIIIIII-“IIIIIIIIIIIIHIIIII-IIIIIIIIIIIIIIIIIIIII lufi Ill-Ill...-III.I.-ll...IIIIIIIIIImIIIIIIII-II'L‘IIIIIIlulu-IIIIIIIIIIIl-I lullnlllililnmlnnlIIIIIIIIIIIIIIIIIILK‘IIIII“II-IIIIIIIIIIIIIII IIIIIIII—IlllmlllIIIIIII.IIIIIll[III-“II-KuIIIIIIIIIIIIuIll-IIII III-III...IIIIn...lIllII'-IIIIIIIIII-III.Ill.IIKIIIIIIIIIIIIIIIIIIIII-l III."-III-ll-IIIIIIIIIIIIIIIIIIIIIIIIII'IIIIIIIHIIIIIIIIIIIIIIIIIIIII III-I'll.-Ill-IIIIIIIIIII-IIIII.IIIIIIIInIIIIIIIHI-IIIIIIIIIIIIIIIIII II".Ill-IIIIIIIIIIIIIIIIIIIIIIII!IIIIIIII-IIIIIIIEIIIII-IIIIIIIIIIIII II.IIIIIIIII-“II[I'll-IIIIIIIIIIIIIII IIIIIl-IIIIIEIIIIIIIIIII-III..- IIIIIIIIIIII_IIIIIIII-III...I-IIIIIII III-ll...-IIEIIIIIIIIIII-lllll II.I.IIIIIIIII-IIIIIIIUIIIHIIlIIIIIIIIII-I-‘IIIIIIIIlliiflillllIIIIIIIIII III-lllfllII-III-IIIIIIIIIIII“llulI-luillI-IlllfllmlllIII-Ill... IIIIIIIIIIIII'IIIIIIIl-IIIIIII'IIIIIIIIIIII‘IIIIIIIIIIII-IIHI'IIIIIIIIIIII Ill-IIIIIIIIIIIIIIIIIII--IIIIIIIIIIlllIlIlIlllllmEllnllflllIllI-IIl-I IIIII-IIIIIIIII-IIIIIIIIIIIIIIIlIIIIIII.II.II'll-IIIIIIIIIMIIIIIIIIII IIIIIIIIIIIII-IIIIIIII-IIIII-IIIIIIIIIIIIIIIIIIIIIII-IIIII'L‘I'll-"III IIIIIIIIIIIIIIIIIIII"IIII.I'll-IIIIIIIIIZIIIIIIIIIIllIII-IIIMIIIIIIII IIIIII-IIIIIIIIIIIIIIIII-IIIIIIllllll'llll-llllm“II-IIIuIflIIIIIIIr "III-III.III-III...IIIIIIIIIIIIIIIIIIIIIulIlI-IIIII-lllmlIII-IIIII III-"III.IIIIIIIIIIIIIIII-IllllnllnllinlllllllIII-IIIIIIIIIIIIIIIL IIIIl-IIIIIIIIIIIIIIIII-IIII-Ili-IIIIIIIll-IIIIIIIIl-III III-IIIIIIII Iuml-IIIIIIIIIIII"II-ul-III-IIIIII"III-IIIIIIIII t; i m D 7? a “w 5‘ Lil- 'fl-I15.cmmrm.lommmm ' LIJE'I} i 3. CT is a IS-year-old 60-h; female with I history of generalized Iorrie-elmie mini-es whom present! to the magma} room with e generalized seizm'e. Her initial seizure is treated with Inrrazepm The medicnlrecrord for CT doe-mutt that she is currently taking Dilanlinfli (Sodimn Phenfiuin) 300 Why; howewr CT admits to not taking her mdiealinne regularly. Her total phenymin plenum eonmfienhrdlefiflisfoundrobezum Herefbmninieinrhenormal range. thyloin "rm": 1= .. n.9, Salt of form Nn‘ thyloin = 0.92 \f =. G (:5 L ha Thmpelniennge: Temlphenyminzlfl—Zflpgfml J Unbounfl phmytoin: 1-2 uyml {31:13) A. Yeuareaskedluealeuluem'mtrevermlmdingdasefmfitu achim nmgelmeuuefieneflfi ”gimL LDfl U-(Cm-{ubh i inesl-hjflmté!GENElL-RMeIQ 5.F-' -2 03:3 fr) L0 = (273' m3 , (5915}B.Hyuudaaddemedminifierthemfiieloadingdmeuannrudm. describe huwyeu Wufladminiflu'itlndexphinwty. PK; OQAE '- QTEIM; = 2’59 m3 0:? jinn“ CW flfi 31.; men ”W“ 35th m3 '3 5&5 {mi TT‘” qgomfi 5 .3 hr;- diff} hi- ..— ra Or fl‘inl “Cr dint {1‘0 ‘fij 1 4. [3pullIJ-IisndD—rur—oldflfi—kgmflefilhlhinoryfifmmpkxpm‘fialm Heufiminyomeliniewithnymumdm Aflnfitfinzllhsincludingn posifiveflhmnlhveLflhmnhphmmmflnfianuflj midlandaloul phenytoinplasmawncmtmionaflfluy'ml Shnwhowyeuwuldruleout Ethanol vs. phenyluin inmxiflliun. _ [U Hjlm 3 3 . .. PHT at [PH-77m 1 I 5 f .r 2;“- [ mm? ”Hg—- . Q_.,.W-).o.. .. . Emu gm: WWW. d; it??? . M Q. ‘1. :3 “-1.153” ihfiJJet‘ Wk]. 4R“ _ I I r {:fi E I U Jenn 4"th i f 5. {I 0 pts} Use the lite following metabolic scheme and data regarding baseline ' . prom-mole] phannaookineties to estimate the mimmn increase in average steady state ofpmpnmlel it": pattern is started on fluencetine. e CYPZDE inhibitor. Elf. Pmpnnolal —*uummiemm HUI. Pwhl +OH-hnprlmhl WW WH-gh-emide l'l' e l.‘ .'. '.- ' II'_.-. |._' 'IL'J' Ia.|.|. Tn'rl'!‘ ..t....._. Her-nee fl: mln‘miml'lrt 11mm ' g Eemm: Q , :53 fl '1: i=1 h h” (gt-,1}. tnhb “9) CH4: 1' .1— thlI-Y‘. u"" _‘_1 it“: 9‘: Clmtt-‘nL (:1 Chat: '" . “Mi Ctr-amt. '5'" “"“"""‘""5 w“ ’ (inmate. +0 “If: m WNW) 9'6 = 0,75 60 _____ ": 1‘ _i_ .1: {Ck/‘7’ x 5:- .--.. DI“?! Zim— cc“ MOT} H _____,...._—-—- onqul 6 A] is a £3 yea: uld male admitted for treaimmt of attial fibrillation. HI: is 6'1!" and weights 129 kg. Mcdical history imiudes mild renal dysfimction mmflary In chronic hypertension. Labomlorr mints include a serum cmfinim of 1.3 5-: i U mgfiil and nibuminn =14 .ii gmr'dl Dig-3min “Facts": VB=I5 ng F = II?!) for ' diguxin tahlcls LIE-N: fléiij+r23}[IJJ-= 77C: Kj (Smith. Calcuiuealuading dosatomgflldigaxinfflnsim communion of 4.3+ Lingfml. LIGm‘. w flaw hue an: m u“. --‘~ ”~th LL: \PQ _._. {EL/Ir?(Tit-raifiis-uafl} F3" 5.: -. rho Hr") . c-if IS'n _._ 3.54“?) LI“ .- wd M3 II/ ” .5"? A’- J' QM L LC): 676).”? _ 9?; "j 0.? l (1911313. Cnlwhteanuhnmdmmmfladigminplam comma-alien of 1.5 nyml. CPC’ // “Wm-0 M 9:3 W/m-u 7;)- Stir Pr“: 10 CHF _kf mifmu pC-‘h :3: ("“1” j: (OIE m.}m"fi5\{7lbif:h if‘iri 3 3 mt. .... 1.1 CircmL. .. /o 9, V ”Fifi-III cu (I5— KT: 09 I mum .__ ‘ .33 0/15 " 3‘5 F t. ) waln- '3'. 3. (I ('24 pits) Fill in the Hanks. with harmed, dtenmfl er III: um: : {2 1313 ml!) Compaitd to adult levels, alhmnin plasma ammunition: m— .11 inmates, H intoddlmnnd 5L [ht eldtrljr. Compandlonduhltmhlhedmmufliuwuuflfimnfifidmglhflis prtdcminnlcly liver WMMMWAWQE H: imam ___’L____in:hildrm3y¢nrsuld and flfiflfi inthaelduiy Compandluflfltkvehfluclflmeofllnwmfionmludmsflmis pmdominnlclyfivumnhbdimdbyflmflmonidafionmmfli: {1-} human. H inchildrcnilymuid Ind influclduly. Compnmdtonduhluwh. mammofldmgflimhmed‘predcrmimdy bymflclunnnuis If 'inmam. H 1- r1- IrI-I-‘i 4-1-1- ‘JHIH-I III-a" ll. '1‘" *h“ FIHFH'U {6:15) Fiflinihebhnhmm'l‘m whine: flpumh) Chutficcirrhmmfltshn 3L influmatnbnlimflfdmgs Mlmwmmmmmuufismmmmmm - imam? a fig Lumisnbeflndmglhmdimpamtobemdinbefledpflimwflh wwwinhmwmbwmmd ' ligation. Will True 3 False EQUATIONS ass-m VmV-DI'I _ {m - Mal-[mm mtmll'mml = —— Inn-null: 72-50 @115: muhifiyflmnbowfifllbyfllfi uwmulu n 501:: + {1.3 firm-cm Inchweri fad} wwftmnhs = 45.5 k3 + [2.3 kg [at curcrymch overhaul} Diplin: WWW: Emultt-BjmlfuinfkfltwlintflHlJ-flaumlfinh} mammal: .«ttmunm.31nummhm+ [u 'Chfl‘umlfmin} r1 {Juan-CI“ CIH=Q ' q- 1 c” = “$51 = may} C“ = I“ (my LIFE?!“ Q — F.{DF) LI =fl£fl “PT ‘3” a [”3111ou [FHInflmfllzed l = d. 0.25—-[A.lb] + 9.1 ...
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