Pceut532_Final_2000 - 1{F‘Lfil any!“ ”FUEL(In{12 pl...

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Unformatted text preview: 1 {F‘Lfil any!“ ”FUEL (In. {12 pl!) - I. For drugs like phenfioin Which ebey Michaelis Manet: kinetics, the value of Km is several fold higher Hum the thetapunie range True False 5 2. Mien a patient receives phendoin I! 1 daily dose :1un to heifof‘u'm‘f. the steady state plasma eeneenunfim is equ! to helfeme True Fake 5 3. WapaflenneeeiveephermomaladnflydosemummVmVJ-Jestefly slate plum eeneeuuafimhemmesmponiamlte daily dose Tm: False (25 at!) 4. A. Cakuluetheemadymphmmmflnneehievedinepafiem teething 3W mgiday efplmnyiuin knowing Ihal: Km = 5 mgfi. va- dflfl myth)! (55‘ = D"? ' rm 3 500:3”“2 - 5m; It. va " D If “resides fawn-Utah‘s Cab“: 15' m3 IL. B. Aflerechange indailydosetheplemeuneenlmion reaches ID my‘L Caleulue Ihe clearance utWoininthispafiem. Cy; fl— - qc’ofifiimfl _. Km*(bb 5‘”ng 1- rot-SJ'L Cl‘ 2L7 LIdfij 625F451 5. SLisa4Syemal¢Tflkngk1misadmimdtolhafikaflcranalmhu! withdrawalseizurg. SLiswcllhmwnmfircERsuffwfihnhiswryof gmmflmdtodwhficmpmdpimdbyflmhnlmdlflkofcmplmw his anticpilcptic mediation. phenytoin. SLhuumda-amhepafic cirrhosisduuo ulflymhiflmy nfalmhnlahflt. ASTAT phmyminlmldflmhmthflSL Mummiphmfluinphmmmfimuflugfmf A. Cflmlncmorflhdhlgdmufsodiumphcnmmxfimaw pinnamnemflnnofliwnd. You mlhhlofindhiywl’mlwfi noteslhflaodiumphenyminisfl.flphcny1¢in.F-fl.9ded-DJ ng. Note: chmdmdhmmwmmhmmduu. i”"’"“-*°*C°® -' (mm): W”: b-F Leanna?) 3hr: fail-a 6:1 «mom; new: ween-.3 23“”; :50»: 1' C . B. SLiudnfluedmlhehafiuitalmdDLNmurdmdiaupmuneedadfm alwhdwhhdnwalsymmmbuymmdfiknwhlvaMWm Iorazapam. Exphianr.Hmuhyyoufulmpamwutdbeahcw druglouscinflfispaficm. Dtczepcm i: mkn‘oeL’yd b1 Cahtw MU (Wig? 9nd lWIevfbcmi'r .Mgbgl;}q {3.5 UGT {Suwéwnq .. - alt-c. WELCm—wfinm is relu'twt“) SPW'J I” mew {2591:} 6. TJisan'hkg. 5'!fl",63yearsoldmalomifiodio1hobospiulfontfinl fibrillation. Modioflhinoryhdudfllmfldmfldysfimfionmondaylo chronichypmumm Lnbaatorynhminohflummnine-lsmgml andllbmnin==235mffl Cnloulm-Ioadingdoauflfinodmimmmdm [orafllotnrgcudigoxin continuation ofljny’ml. ‘fiD mums?“ 6m: -F'=fl1flfordigofin ”fl-39mg“: 301(3 {- (manna) .. 7:3: 1:3 (2rd (Minx...) .e (HO-GB)‘{73) .: £40.43 m'fmuJ E72} {3-35 Dir Mfg. QHF C1 (“limp-o» .. (10.5 m‘lmwftjw(73 kj)+- (LI 1: 140.9 min“) = [03: I "“J'm'd F-le CI _ C__§___F____s"C} — (15' “51mg (1%.! Mil-n3 _ 33* "3.5 1mg lerlmhmmdfiflmwommfldysflmfimwmmdbe mmbhnwflhhwmuhdnmdfinminmblmo. THE 5% Cf‘echnme W1 5%” b9 {‘13: “j Sig-ad S-‘rob. horn (kt. bEEn mocked mlp 5C1} mosh: OWoW~mMI3 ngIEOHH't-S 4 . ‘- ufi 1m} L03? 3. Ammflfihlmmmflhfljuflmmmmd. his '5'" pnduminawb'fimimtedhyhepaflcmehhoflsmvhmutfiphmflfi pathways. illhhbmmthmcmemeSM Cd. M“ :hfi M cumming . .l._l .4“. n J '. ‘1‘ a Tadphmncmmummlmmube 11-44 be? I?- 9N La 1:. Unbomdplmcnmafinnshamwiflbe ] . g: c. Tomwummmmmmmmouwmh J: _ a; a. Unboundemrfliumhlchild4ymuMH-fllbe J; . a. Toulplmmmulfiminmflflymoflwiflbe 14.9 r. Unhounflplummmtmfiominmfiflymnldwiilbe ’f‘ . (5 Ilia} LEHPhinWiimiEiifi-Q, " ' * \r IS W Ti-Sl‘fi'dr PKch. bina‘j . I an W Gui: ”'11 appmfi Udumu: (a H1 {amt-m. - w magma 01.9.9. con (may; mm alt-H- 03w 4 {5w} ' 1D. AfloffiMwWWhlflmfimfldeI-nflim mmmummlmmflmmmlmbim The 1 _ efiminflimhflffifhhflmmmhamwflhimmtwmz ammanddecmsedudlhz. Explainhawdfismm. - (511m. we :5 W DH fad-h C! w v’ {14 Pt!) II. JChaeb-eenreoeiving pmpunnnlolfimgfday fetihelastfiyearsfni'mimine prophylaxis. After having a flurry efmigreinee Ihe last 3 months, his physininn adds vnlptnie acid 10W my’dny. Vniproie Heidi is a known inhibitnr Inf glueurnnidatinn. Ghren the follnwinametabofie scheme and the percent ni‘dnse accented for by each metabolite, calculated the madman increase in steady state prnpminlol enneennntinns lint-JG emfld have when mimic acid was added. CY?!“ [HIT Prom-obi —* 4-DH-prnpmnnlnl—‘P 4-DH-glumn'nnide TV (20%] {2m lea-r “LA Propranninl gjuewmide {TM} {1.5%} . urine urine wine will , PRU") Glu‘c it; IS ”/6 a; Clem-em +£54.91 ieamcfl {(30% inth—ibq wt: 0an from c, . (33 2")" 70 C53 = Iii/”t "‘ 1 Ci “I win. 0.33.121 _L. C33 {mu T in) 0.3: .= Air/36X.— #- . I r' ' ' - . -i i Anu‘ziromt— £5.11. “"ka $61"? “JAM T Ltd-1‘: riff-”:39 FIE-w _F_ f 1, {11 Ills} Trill! ur FIJI: or E]! In the blank: (3 pH nah} ll FelbammisbolhmilflmrofCYPSA4uflminhihfimquYP2C19. Afifl mum-pr fimfilbmamthefimc lumuimtm indmionafulrug mumwcwammmmymubemm-mm finntomflnminifibifionahdmgmahcflmflby C'I'HCIMplnywh-l). Tm at. (”.01'IW 13. haddifimmfelhanm. Ema-unfit}! [Efrain wninhibitnrnfdmgs mmwcmu. 14. Elucxmg fl inninhibimwfdrugs mmwcmm 15. WWinmdcubmmpimmumdcmcmflthcwmim rIWI-‘ILU V: will: WIIIHIlH-u I'd III'IiHJLI'I'h-l True or {‘1 P“) lfi. thnvalpmicacidislddedmthemmpynfnpihunmflymhflm WWWWWWJI or 1-“! whileunhmdein plasma mmflflmwfll 1|: __g mmlamicacidisbothm “MU diwh M /. . EQUATIONS Caz-Db: :- Km VmV-th . _ {140 - A8¢)'G—BW} CrClljmlfmm} — “72-30 .mm , rams: multiply the slum CICI by 9.35 LBW” = 50 kg 4- (2.3 kg for way inch over 5 feet) 1.me -= 45.5 kg + {2.3 kg farm inch oven-5 feet) Patiuqta without CHI": m'l INN-l -. "CI tot-n1 = {0.3 mvmnrkg) (wt in kg} + (1.1 t mm. H mm} Pltflmt with our ' " {:1 total = {0.33 mUminfng {wt in kg} + {1.1 -. Gin-1' as mumin} Cf» fifp‘c‘ffl Cl“ =9 C =F'£D#J=F*(DFJ c: upwm ' "T's ‘ th: “ Q cg: F‘UJE) anertwm O C’“ 9 ...
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