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Pceut532_Exam3_2008 Blank - PHARMACEUTICS 532 Winter 2008...

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PHARMACEUTICS 532 Winter 2008 Midterm #3 February 29 th Name_______________________________________ Student #____________________________________
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Page 2 of 9 Questions Points 1. 9 2. 10 3. 6 4. 6 5. 6 6. 3 7. 15 8. 10 9. 21 10. 5 11. 9 Total 100
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Page 3 of 9 1) (9 pts) Answer the following questions true or false a. As plasma concentrations increase and approach the K m of the drug’s major clearance pathway, a change in the dose produces more than a proportional change in the plasma AUC. TRUE_____ FALSE_____ b. The rate of decline of effect with time is dependent on the elimination rate constant (K) and the slope of the effect-Log concentration curve. TRUE_____ FALSE_____ c. For a drug demonstrating Michaelis-Menten pharmacokinetics, the clearance of the drug is independent of the plasma drug concentration when it is much below the Km. TRUE_____ FALSE_____ 2) (10 pts) A patient who was given phenytoin at 300 mg/d had a phenytoin plasma concentration of 10.5 mg/L. The same patient was given phenytoin at 350 mg/d that resulted in a plasma phenytoin concentration of 13.5 mg/L. Using the Ludden method, determine the V max and K m for this subject and the dosing rate necessary to achieve a plasma phenytoin concentration of 17mg/L. DR/Css DR 300mg/day/10.5 mg/L=28.57 300mg/day 350 mg/day/13.5 mg/L=25.93 350mg/day 3) (6pts) Provide a definition for the following parameters: a. E max : ____________________________________________ b. EC 50 :____________________________________________
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Page 4 of 9 4) (6 pts) In the space next to the plots below, identify which parameter is different
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