Pceut532_Exam3_2007 Key

Pceut532_Exam3_2007 Key - Winter 2007 Midterm #3 Feb....

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Winter 2007 Midterm #3 Feb. 23,2007 Name ~- Student # a - - -
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Questions Points 7. 8. 9. 10. 11. , 12. 13. 14. 15. 16. 17. 18. TOTAL
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Student # - - -- . - ... - - Part I. Check or fill in the appropriate answer 1. The absorption, distribution and elimination of lipophlic drugs are not affected by membrane transporters because these molecules have high LogP values and can freely cross cell membranes by simple diffusion. (3 pts) True- K False - 2. Valganciclor, the prodrug of ganciclovir, has a much higher oral bioavailability than gancyclovir because it is a substrate of the intestinal peptide transporter PepTl whereas 3 ganciclovir is not. (3 pts) True L iq False 3. Drugs with oral bioavailabilities < 50% exhibit small increases in oral AUC as a result of ). C*~A inhibition. (3 pts) V True False A 4. - Enzyme inducers decrease the AUC of orally administered drugs by decreasing the fraction escaping gut wall metabolism and the fraction escaping hepatic metabolism. 5. Protein binding-based drug interactions involving low extraction ratio drugs are generally not clinically significant. (3 pts) /- True False 6. Name two drug transporters in the kidney 0 c T 2 , .oh 7 1 > 7. e three clinically important CYP2C9 substrates ~m /iCt\ 3 %%r+A*rde and rhc~yh~h .(3pts)
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8. Name two CYP3A inducers (3 pts) Name a substrate and an inhibitor for CYP2D6 (3 pts) Substrate I i r 1% i inhibitor q n ln I* i h r 10. Provide one example of a CYPlA2 inhibition drug interaction (3 pts) Substrate cn$P ~h e inhibitor f bt Vrr 0 h 1 A e 11. Which of the following statements is not true regarding the drug transporter P-gp. (5 pts) 5- a. P-gp is a primary active ABC transporter that utilizes the energy generated from ATP hydrolysis to efflux drugs out of cells. b. The role of P-gp in oral bioavailability is profound and hard to discern from CYP3A because P-gp and CYP3A enzymes are co-localized in the enterocytes and share a large overlap of substrates and inhibitors.
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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Pceut532_Exam3_2007 Key - Winter 2007 Midterm #3 Feb....

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