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Pceut532_Exam2_2008 Key - PHARMACEUTICS 532 Winter 2008...

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Page 1 of 8 PHARMACEUTICS 532 Winter 2008 Midterm #2 February 11 th Name_______________________________________ Student #____________________________________
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Page 2 of 8 Questions Points 1. 30 2. 9 3. 10 4. 10 5. 5 6. 36
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Page 3 of 8 1) (30 pts) Answer the following questions true or false a. After oral dosing, the maximum plasma concentration occurs at a time, Tmax, when the absorption rate equals the elimination rate. TRUE__X___ FALSE_____ b. Drug metabolizing enzymes and efflux transporters in the intestine act to increase the bioavailability of many drugs. TRUE_____ FALSE__X___ c. After oral administration, the fraction of dose lost by hepatic first pass metabolism can be predicted from hepatic clearance. TRUE__X___ FALSE_____ d. At steady state, the amount of a drug in the body is constant. TRUE_____ FALSE__X___ e. The time to reach steady state is determined solely by the elimination rate constant of the drug. TRUE___X__ FALSE_____ f. The average steady state plasma concentration of a drug is dependent on its volume of distribution. TRUE_____ FALSE__X___ g. The time to reach steady state is decreased when volume of distribution is increased. TRUE_____ FALSE__X___ h. In a given individual, an increase in clearance will shorten the time to reach steady state, and lower the C ss . TRUE___X__ FALSE_____ i. The steady state accumulation (multiple dosing factor) of a drug is independent of the dose. TRUE__X___ FALSE_____ j. The degree of fluctuation of a drug at steady state is increased when the dosing interval ( τ ) is increased relative to the half-life of the drug.
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