Pceut532_Exam2_2008 Blank

Pceut532_Exam2_2008 - PHARMACEUTICS 532 Winter 2008 Midterm#2 February 11th Name Student Page 1 of 8 Questions 1 2 3 4 5 6 Points 30 9 10 10 5 36

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Page 1 of 8 PHARMACEUTICS 532 Winter 2008 Midterm #2 February 11 th Name_______________________________________ Student #____________________________________
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Page 2 of 8 Questions Points 1. 30 2. 9 3. 10 4. 10 5. 5 6. 36
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1) (30 pts) Answer the following questions true or false a. After oral dosing, the maximum plasma concentration occurs at a time, Tmax, when the absorption rate equals the elimination rate. TRUE_____ FALSE_____ b. Drug metabolizing enzymes and efflux transporters in the intestine act to increase the bioavailability of many drugs. TRUE_____ FALSE_____ c. After oral administration, the fraction of dose lost by hepatic first pass metabolism can be predicted from hepatic clearance. TRUE______ FALSE_____ d. At steady state, the amount of a drug in the body is constant. TRUE_____ FALSE______ e. The time to reach steady state is determined solely by the elimination rate constant of the drug. TRUE______ FALSE_____ f. The average steady state plasma concentration of a drug is dependent on its volume of distribution. TRUE_____ FALSE______ g. The time to reach steady state is decreased when volume of distribution is increased. TRUE_____ FALSE______ h. In a given individual, an increase in clearance will shorten the time to reach steady state, and lower the C ss .
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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Pceut532_Exam2_2008 - PHARMACEUTICS 532 Winter 2008 Midterm#2 February 11th Name Student Page 1 of 8 Questions 1 2 3 4 5 6 Points 30 9 10 10 5 36

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