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Unformatted text preview: ./ PHARMACEUTICS 532
Winter 2008
Midterm #1 I January 25th Néme Kaz ' I I Student # Questions v Points 1 15
2 5 3 ‘ 16
4 JP
5 4 ‘
6 15 1. (15 points) Check the appropriate answer a.The wellstirred model of the liver describes hepatic clearance as: a]:
=g—f”—CZ—m—. Based on this model
Q ‘+ 12%:
Enzyme induction will increase the hepatic clearance of a high extraction
ratio drug '
3P1} ~ > True False K _ Decreased plasma protein binding will increase the hepatic clearance of
low extraction ratio drug  3 W} True False
Hepatic extraction ratio is defined as CL*Q
3 01373 ‘ True ' False X .
IPharmacokinetic (enzyme;_kinetic) parameters determined in vitrocan be
scaled (extrapolated) to in vivo clearance. “ . " 0’73 True False
 A drug with high hepatic clearance will have an extraction ratio of 710.
3P7.) True False X ' 2. (5 points) Belbw is unbound fractiondata for three drugs. Predict the rank order
’ of their volumes of distribution (Rank them based on V as lowest, medium and
highest, an empty column is provided to present any calculations you may need) lb f 0 01 6;:
m
Wm
Wm 3. (16 points) Calculate the following values. Please show the equations you used '
to obtain the values in your answer. After a 5.6 mg/kg i.v.dose theophylline kinetics can be described by the equation: . 70 K _ _ #5561 L ﬁ 6 J) :3 2M9— 5.8t 0.16t '4 0056 g: 70k ?
Concentration is given in units of ug/mL and time in hours. Calculate 
a. The volume of distribution of the entral co Pirtment for theo hylline
Vc . ” = /3l b. The distribution halflife for theo ‘
a. 60/ 3 _ 0. f3
‘ 575’ —
. 0. Plasma concentration of theophylline 3 hours afterthew. dose —£&(:D  .(J) —
C4 ‘ ’35 H a a! ( = 35z’l'laq1ll.) JIM”;th d. The AUC of theophylline ’4‘46"; A+_B__ )ZM "I +’/.5’A)ZJ~I _ a; ,, 1; x ' ﬁrst The pharmacokinetics of procainamide follow a 2Compaftmen'tn‘i0d'el. LT I‘ ’
"The therapeutic and toxic effects of procainamide 'are associated with the central or compartment 1. Based on the following pharmacokinetic parameters, calculate a loading dose(s) in order to target a therapeutic concentration of 6 mall. in a .50 kg patient. ' V1: 0.7 L/kg VB = 2.0 L/kg 7—67,.) pa“ = TD : is 2 2969‘”
T1/2a=5min T1/2B=3h1‘ ‘ m
S = 0.87 procainamide HCL ' 2;]: F = bioavailability = 1.0 for IV TDLJﬁ 7A.; =3 630mg. Therapeutic range: 48 mg/L __ , LD=V*C  Acadia»; 0052. l : [D : __ 0.7%9I5v1z3Y6h3/
F *S a r I I: ‘5 Qﬂhg,
anal2115‘; 401‘— L 670 " m = may I NM (5m) CW Wu st gay/L ' .1052 3 chﬁ‘dzM—CW; (0.7%9X3D/9)[[~w£‘5a;ﬂ)_‘20
7w . W 150mg» ‘4’“ few??? C : 5.77/4.
005:2} Rea/MA. ~ 250*“; @ 170 a
IYO ha}, @— t;3~h‘h~ _ 57w) (4 pts) The pharmacokinetics of digoxin follows a 2—compartment model. The gm;
therapeutic and toxic effects of digoxin‘are associated with the Eerie/mat [
compartment. Therefore, after a complete loading dose, the digoxin serum  concentration obtained immediately after dosing will be 413 45/ 9673
than the recommended therapeutic range (15 pts) The frames below depict a plasma concentrationtime curves for a drug
after an iv. dose of 100 mg; Using the same frames and the space provided next
to each one of them sketch how the curve would look and how CL, V, Co, t1/2 and
AUC would change in each case if I ~
a. The clearance (CL) of the drug doubled CD : Nc: Cbt‘amﬂ logC ,
T72. 1 ‘1’ 23‘
k V : Neal‘wa time b. The volume of distribution (V) doubled s?‘
31'
A
3? [MAC  No charge.
6" :_ N0 almané—L 7. (35 pts) A 54 kg woman was given a _4 mg/kg ivbolus of an antibiotic.
Plasma concentrations of the antibiotic were measured as follows: Time hours Plasma con entration m /L ~ )— o.25 ( ) 8 C .( g )9352 :GV/Qéqk; “QM”?
1.0 ' .  7 6 , 3 12 5 1 a. 'Using the graph paper provided on the next page, draw the, plasma
"concentrationtime curve of this drug. Write the equation that best describes the plasmaconcentration of this drug in this patient as a function of time. a  0.18117
a _— S». Li a
b. Calculate the values for volume of distribution and t1/2.
VI : '2— :. 22,6335: = I _ 0.673_ a575_
17%“ K 7 44k. ',. 36] iv; o. This antibiotic has a minimuminhibitory concentratio'ntMl'C) in plasma thatris ~ mg/L. What is thefduration‘o'f activity ’of this ‘d‘rug‘ inithis patient?  r o.1$'( 6 . . ’
2 mg/Hsﬁ‘té 9 D =a Jim/0110C): .0"m_9_
, 'm m ’x w 8””
_F vamp 1;:777463gA/5 d. If the dose was doubled what would bethe duration of activity and halflife? ‘er ate/awn car: (Jami, ml 59, lac/fayax 57
OM& tYL (“L/1V5) .57 ﬁfauﬂlﬁ’} 74% date. *j’zlerdvre/
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