Pceut532_Exam1_2008 Blank

Pceut532_Exam1_2008 Blank - PHARMACEUTICS 532 Winter 2008...

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Unformatted text preview: PHARMACEUTICS 532 Winter 2008 Midterm #1 January 25 th Name_______________________________________ Student #____________________________________ Questions Points 1. 15 2. 5 3. 16 4. 10 5. 4 6. 15 7. 35 1. (15 points) Check the appropriate answer a.The well-stirred model of the liver describes hepatic clearance as: int int * Cl f Q Cl f Q Cl u u + = . Based on this model -Enzyme induction will increase the hepatic clearance of a high extraction ratio drug True_________ False________ -Decreased plasma protein binding will increase the hepatic clearance of low extraction ratio drug True_________ False________ -Hepatic extraction ratio is defined as CL*Q True_________ False________ -Pharmacokinetic (enzyme kinetic) parameters determined in vitro can be scaled (extrapolated) to in vivo clearance. True_________ False________ - A drug with high hepatic clearance will have an extraction ratio of 7-10....
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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Pceut532_Exam1_2008 Blank - PHARMACEUTICS 532 Winter 2008...

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