PCEUT532_Midterm-2-2009_final_key5B15D

PCEUT532_Midterm-2-2 - PHARMACEUTICS 532 Winter 2009 Midterm#2 February 12th Name_KEY Student Questions 1 2 3 4 5 6 7 8 Points 44 6 6 6 9 24 5 15

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PHARMACEUTICS 532 Winter 2009 Midterm #2 February 12 th Name________________KEY_______________________ Student #____________________________________
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Page 2 of 9 Questions Points 1. 44 2. 6 3. 6 4. 6 5. 9 6. 24 7. 5 8. 15 bonus points
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Page 3 of 9 1) (44 pts) Answer the following questions true or false a. Everything else being equal, decreasing the elimination half-life of an orally administered drug will result in an increase in the Tmax and Cmax of the drug. TRUE_____ FALSE__x___ b. For a drug to be absorbed from an extravascular site, it must be in solution. TRUE__x___ FALSE_____ c. Most of an orally administered drug is absorbed in the small intestine rather than the stomach because of the greater solubility of drugs in the almost neutral pH environment of the intestine. TRUE_____ FALSE__x___ d. At steady-state, assuming linear pharmacokinetics, doubling the oral dose of a drug will double its ! 0 AUC . TRUE__x___ FALSE_____ e. After oral administration of a drug, Cmax is attained when the rate of elimination exceeds the rate of absorption. TRUE_____ FALSE___x__ f. When a drug is infused IV, the time to reach 87.5% of the steady-state plasma concentration will be equal to 3.3 half-lives of the drug. TRUE_____ FALSE__x___ g. At steady state, the amount of a drug in the body is not necessarily constant. TRUE__x___ FALSE_____ h. After an IV infusion, the steady-state plasma concentration of a drug is dependent on both volume of distribution and the clearance of the drug. TRUE_____ FALSE__x___ i. A drug’s steady-state plasma AUC over a 12 hr dosing interval is 120 mg . h/L. Therefore, its average steady-state plasma concentration is 10 mg/L TRUE__x___ FALSE_____
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Page 4 of 9 j. When a drug is administered at a dosing interval that is much shorter than its half-life, its accumulation and fluctuation will be large. TRUE_____ FALSE__x___
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This note was uploaded on 01/31/2010 for the course PHCOL 402 taught by Professor Storm,d during the Spring '08 term at University of Washington.

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PCEUT532_Midterm-2-2 - PHARMACEUTICS 532 Winter 2009 Midterm#2 February 12th Name_KEY Student Questions 1 2 3 4 5 6 7 8 Points 44 6 6 6 9 24 5 15

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